Flexible, self-powered, miniaturized, ultrasensitive flow sensors are in high demand for human motion detection, myoelectric prosthesis, biomedical robots, and health-monitoring devices. This paper reports a biomimetic nanoelectromechanical system (NEMS) flow sensor featuring a PVDF nanofiber sensing membrane with a hydrogel infused, vertically aligned carbon nanotube (VACNT) bundle that mechanically interacts with the flow. The hydrogel-VACNT structure mimics the cupula structure in biological flow sensors and gives the NEMS flow sensor ultrahigh sensitivity via a material-induced drag force enhancement mechanism. Through hydrodynamic experimental flow characterization, this work investigates the contributions of the mechanical and structural properties of the hydrogel in offering a sensing performance superior to that of conventional sensors. The ultrahigh sensitivity of the developed sensor enabled the detection of minute flows generated during human motion and micro-droplet propagation. The novel fabrication strategies and combination of materials used in the biomimetic NEMS sensor fabrication may guide the development of several wearable, flexible, and self-powered nanosensors in the future. NPG Asia Materials (2017) 9, e440; doi:10.1038/am.2017.183; published online 27 October 2017 INTRODUCTION Nature's designs have long inspired researchers aiming to find technical solutions and develop novel and advanced engineering systems. 1 Biological sensors are an example of a natural design that has intrigued scientists over the years. These sensors, for example, flow sensors, acoustic sensors, and chemical sensors, have developed high efficiencies, compactness, responsivity, and sensitivity through evolution over billions of years. 2 Most man-made artificial sensors scarcely match the performance of these natural sensors. Hence, for the development of novel sensors with high performance and sensitivity, it is desirable to apply designs from natural sensors to artificial engineering materials.Hair cell mechanoreceptors belong to a class of well-developed natural sensors ubiquitously found in many living organisms such as insects, amphibians, fishes, and mammals. 2 These natural transducers respond to a variety of environmental stimuli and are capable of sensing pressure, flow, acoustic waves, and chemicals. Some examples include air flow sensors in crickets, air flow and vibration sensors in spiders, water flow sensing whiskers in harbor seals, neuromast acceleration sensors in fishes, and cilia in the organs of mammals, including the taste buds on the tongue and cilia in the nose, lungs, and inner ear cochlea. [1][2][3] In aquatic environments, these hair cells have