A literature review on the role of miR-370 in disease

Zhu, Jie; Zhang, Bin; Song, Wenfeng; Xie, Zhaoxiong; Wang, Lei; Yin, Bowei; Zhu, Fangfang; Yu, Chaohui; Li, Hong

doi:10.1016/j.genrep.2016.02.005

Cited by 5 publications

(2 citation statements)

References 106 publications

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“…The discovery of miRNAs dates back to 1993, when Lee et al first identified them in Caenorhabditis elegans (107). miRNAs are widely recognized for their role in regulating several physiological and pathological processes like regulating the cell cycle, metabolism, signal transduction, and apoptosis (108,109).…”

Section: Biological Features and Biogenesis Of Mirnasmentioning

confidence: 99%

The role of non-protein-coding RNAs in ischemic acute kidney injury

Sabet Sarvestani,

Afshari,

Azarpira

2024

Front. Immunol.

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Acute kidney injury (AKI) is a condition characterized by a rapid decline in kidney function within a span of 48 hours. It is influenced by various factors including inflammation, oxidative stress, excessive calcium levels within cells, activation of the renin-angiotensin system, and dysfunction in microcirculation. Ischemia-reperfusion injury (IRI) is recognized as a major cause of AKI; however, the precise mechanisms behind this process are not yet fully understood and effective treatments are still needed. To enhance the accuracy of diagnosing AKI during its early stages, the utilization of innovative markers is crucial. Numerous studies suggest that certain noncoding RNAs (ncRNAs), such as long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), play a central role in regulating gene expression and protein synthesis. These ncRNAs are closely associated with the development and recovery of AKI and have been detected in both kidney tissue and bodily fluids. Furthermore, specific ncRNAs may serve as diagnostic markers and potential targets for therapeutic interventions in AKI. This review aims to summarize the functional roles and changes observed in noncoding RNAs during ischemic AKI, as well as explore their therapeutic potential.

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Section: Biological Features and Biogenesis Of Mirnasmentioning

confidence: 99%

The role of non-protein-coding RNAs in ischemic acute kidney injury

Sabet Sarvestani,

Afshari,

Azarpira

2024

Front. Immunol.

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“…Zhu et al 83 used an injectable selfassembling peptide-based hydrogel for the delivery of adipose-derived stem cells (ASCs) that were pretreated with dimethyloxalylglycine (DMOG), an HIF-1a activator, into the necrotic area for the treatment of osteonecrosis of the femoral head in rabbits. Bone regeneration and vascularization in the necrotic area were improved when DMOG-treated ASC-laden hydrogel was transplanted as compared with core decompression alone or transplantation of untreated ASCs.…”

Section: Hydrogel-based Scaffoldmentioning

confidence: 99%

Cell-Based and Scaffold-Based Therapies for Joint Preservation in Early-Stage Osteonecrosis of the Femoral Head

et al. 2019

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Numerous basic-science and translational studies of cell-based and scaffold-based therapies are currently being performed. » The advantages and limitations of cell-based therapy for osteonecrosis of the femoral head, including bone marrow-derived mononuclear cells (BM-MNCs), mesenchymal stem cells (MSCs), and MSC-derived exosomes, are being examined preclinically. » A range of ceramic-based, polymer-based, hydrogel-based, and composite scaffolds have been used for the treatment of osteonecrosis of the femoral head in order to physically or functionally support bone repair and remodeling. » Modulation of the pro-inflammatory response at an appropriate time point has enhanced bone formation in experimental models. The therapeutic potential of these strategies in translational models of osteonecrosis of the femoral head has not been fully clarified.

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