2011
DOI: 10.1186/1743-8977-8-4
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A living cell quartz crystal microbalance biosensor for continuous monitoring of cytotoxic responses of macrophages to single-walled carbon nanotubes

Abstract: BackgroundNumerous engineered nanomaterials (ENMs) exist and new ENMs are being developed. A challenge to nanotoxicology and environmental health and safety is evaluating toxicity of ENMs before they become widely utilized. Cellular assays remain the predominant test platform yet these methods are limited by using discrete time endpoints and reliance on organic dyes, vulnerable to interference from ENMs. Label-free, continuous, rapid response systems with biologically meaningful endpoints are needed. We have d… Show more

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Cited by 37 publications
(21 citation statements)
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“…Quartz crystal microbalance (QCM) transducers are widely used mass‐sensitive sensors in the field of biosensor design, where the acoustic wave platforms serve as sensitive elements during surface binding events . The QCM has been also successfully applied to study cell adhesion, the surface spreading of living cells, the interaction of antibody with growth factor receptors of cancer cells, and cell responses when exposed to nanoparticles and nanotubes . Tymchenko et al used the QCM with dissipation monitoring (QCM‐D) biosensor setup to study the biomechanical properties of stem cell CM clusters.…”
Section: Methods Results and Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Quartz crystal microbalance (QCM) transducers are widely used mass‐sensitive sensors in the field of biosensor design, where the acoustic wave platforms serve as sensitive elements during surface binding events . The QCM has been also successfully applied to study cell adhesion, the surface spreading of living cells, the interaction of antibody with growth factor receptors of cancer cells, and cell responses when exposed to nanoparticles and nanotubes . Tymchenko et al used the QCM with dissipation monitoring (QCM‐D) biosensor setup to study the biomechanical properties of stem cell CM clusters.…”
Section: Methods Results and Discussionmentioning
confidence: 99%
“…168 The QCM has been also successfully applied to study cell adhesion, 169,170 the surface spreading of living cells, 171,172 the interaction of antibody with growth factor receptors of cancer cells, 173 and cell responses when exposed to nanoparticles and nanotubes. 174…”
Section: Quartz Crystal Microbalance Transducers With Dissipation Mmentioning
confidence: 99%
“…Furthermore, during the electrodeposition process, Co(OH) 2 prefers to grow into a plate or flake shape and finally to form a porous film due to its intrinsic lamellar structure. This porous structure is highly desirable for enhanced electrochemical reaction kinetics in supercapacitors due to the large surface area, easy access to the electrolyte, and reduced mass and charge diffusion distances [11]. Although the electrodeposition of Co(OH) 2 has been extensively studied under different conditions through a variation of synthesis parameters such as applied current density and potential as well as bath concentration, pH, and temperature [12][13][14], the use of pulse current (PC) for the deposition of Co(OH) 2 has not been reported in the literature.…”
Section: Introductionmentioning
confidence: 99%
“…Many biosensor applications in the field of detecting biological agents exist, which are based on the QCM technique (reviewed inŞeker and Elçin 2014). For example, those involve the measurement of enzymes (Bouchet-Spinelli et al 2013,Şeker et al 2010, proteins (Crosson and Rossi 2013), nucleic acids (Papadakis et al 2012), bacteria (Kengne-Momo et al 2012) or mammalian cells (Wang et al 2011). QCM technique was initially introduced to monitor the mass adsorption of chemical species in gas phase on a quartz surface.…”
Section: Introductionmentioning
confidence: 99%