A Local-Anæsthetic Solution With Longer Action

Loder, R. E.

doi:10.1016/s0140-6736(60)91485-9

Cited by 30 publications

(8 citation statements)

References 1 publication

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“…In the search for longer-acting local anaesthetic solutions, various adjuvants to available agents have been tried. Among these, clinical dextrans have been the subject of both clinical and experimental studies since the initial report of Loder (8). Subsequent investigations have, however, given conflicting results.…”

Section: An Et Almentioning

confidence: 99%

Effects of Adjuvants to Local Anaesthetics on Their Duration

Hassan¹,

Renck²,

Lindberg³

et al. 1985

Acta Anaesthesiol Scand

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Local anaesthetics of the amide type were studied in a modified rat infraorbital nerve block model, with which it was possible to determine varying degrees of sensory block. Of the agents investigated, 0.5% bupivacaine tended to give a longer duration of block than 2% prilocaine or 2% lidocaine, while 0.5% etidocaine had the shortest duration. The duration of prilocaine was prolonged by addition of adrenaline, 5 micrograms/ml, more than that of the other agents. Addition of dextrans of Mw 40-110 X 10(3) did not cause any prolongation of block induced by bupivacaine. When mixed with dextrans over a wide range of Mw (40-4900 X 10(3), prilocaine exhibited significant prolongations of its action by up to 200%. The extent of prolongation was dependent on the degree of block, the concentration of dextrans in the local anaesthetic solution, and the Mw of the dextran although in a less uniform way. An increase in the relative viscosity of the solutions might be a factor of importance for the prolonging effect of addition of dextran to local anaesthetics. Since a formulation providing analgesia of a long duration would be of clinical value, further studies on combinations of the comparatively low-toxicity agent prilocaine and macromolecular substances are of interest.

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Section: An Et Almentioning

confidence: 99%

Effects of Adjuvants to Local Anaesthetics on Their Duration

Hassan¹,

Renck²,

Lindberg³

et al. 1985

Acta Anaesthesiol Scand

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“…

It has been shown that when 1 % lignocaine in 10% Dextraven with 1:250,000 adrenaline is injected into the correct site at the end of an intrathoracic operation there is relief of pain for four to 16 hours (Loder, 1960).Patients now receive these injections routinely at the Thoracic Surgical Centre at Papworth. The exceptions are children under the age of 7 years, patients with coarctation of the aorta, and, until recently, those cardiac patients operated on under hypothermia or by use of cardiopulmonary bypass.

…”

mentioning

confidence: 99%

“…It has been shown that when 1 % lignocaine in 10% Dextraven with 1:250,000 adrenaline is injected into the correct site at the end of an intrathoracic operation there is relief of pain for four to 16 hours (Loder, 1960).…”

mentioning

confidence: 99%

A Long-acting Local Anaesthetic Solution for the Relief of Pain after Thoracotomy

Loder¹

1962

Thorax

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“…It has been demonstrated by several investigators (May 1951;Dahn 1953;Hohmann 1954;& 1956;Loder 1960;Chinn & Wirjoatmadja 1967;Nolte et al 1967;Kromer 1969) that the addition of dextran to local anaesthetic solutions will prolong the anaesthetic effects.…”

mentioning

confidence: 99%

Studies on the Duration of Local Anaesthesia: A Possible Mechanism for the Prolonging Effect of Dextran on the Duration of Infiltration Anaesthesia

Åberg

Friberger

Sydnes

1978

Acta Pharmacologica et Toxicologica

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The mechanism of the prolonged effect of dextran on the duration of local anaesthesia has been studied. Using radio-active mepivacaine it was found that dextran prolonged the duration of infiltration anaesthesia in guinea-pigs by delaying the absorption of the local anaesthetic agent. Experiments in vitro indicate that molecular complexes between the local anaesthetic and dextran may be formed and it is assumed that the delayed absorption might be due to the formation of such molecular complexes. This hypothesis was strengthened by experiments in which dental infiltration anaesthesias were performed in healthy volunteers.

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A Local-Anæsthetic Solution With Longer Action

Cited by 30 publications

References 1 publication

Effects of Adjuvants to Local Anaesthetics on Their Duration

Effects of Adjuvants to Local Anaesthetics on Their Duration

A Long-acting Local Anaesthetic Solution for the Relief of Pain after Thoracotomy

Studies on the Duration of Local Anaesthesia: A Possible Mechanism for the Prolonging Effect of Dextran on the Duration of Infiltration Anaesthesia

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