Java is the most populous island in the world. Data from BPS states that its population growth will reach 167,325,600 people by 2035. The population is directly proportional to the number of motorized vehicles, land use, and reduced vegetation cover. Hence, carbon monoxide increases as time goes by. Awareness about carbon monoxide is needed because CO is dangerous for human health. From several studies that have been carried out, several types of vegetation can reduce CO (carbon monoxide) pollutant levels to the maximum. Several studies conduct studies and analyses on plant estimates for CO pollutant absorption. Most of them analyzed the vegetation and carbon monoxide in a bio-chemical framework. This study was conducted to determine the relationship between CO and vegetation represented by NDVI from a spatio-temporal perspective. The study used CO data from Sentinel-5P for three years, NDVI, and land cover data from MODIS. From this research, NDVI and Carbon monoxide have an opposite relationship due to the correlation between both variables being -0.603. This result means NDVI and carbon monoxide have a strong negative correlation: the more vegetations exist, the less carbon monoxide content in the air.