A Longitudinal Evaluation of Cognitive Fatigue on a Task of Sustained Attention in Early Relapsing-Remitting Multiple Sclerosis

Berard, Jason A.; Smith, Andra; Walker, Lisa A.S.

doi:10.7224/1537-2073.2016-106

Cited by 25 publications

(43 citation statements)

References 33 publications

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“…A corollary of this interpretation is that MS patients probably need to increase their engagement of alerting and orienting mechanisms to improve their reaction in each trial to relocate their attentional focus as fast as possible. The maintenance of this strategy to compensate for the deficit is probably the cause of cognitive fatigue observed in some cases among MS patients during sustained attention tasks 63,64 .…”

Section: Discussionmentioning

confidence: 99%

Altered phase and nonphase EEG activity expose impaired maintenance of a spatial-object attentional focus in multiple sclerosis patients

Vázquez‐Marrufo

Sarrias-Arrabal

Martı́n-Clemente

et al. 2020

Sci Rep

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Some of the anatomical and functional basis of cognitive impairment in multiple sclerosis (MS) currently remains unknown. In particular, there is scarce knowledge about modulations in induced EEG (nonphase activity) for diverse frequency bands related to attentional deficits in this pathology. The present study analyzes phase and nonphase alpha and gamma modulations in 26 remitting-relapsing multiple sclerosis patients during their participation in the attention network test compared with twenty-six healthy controls (HCs) matched in sociodemographic variables. Behavioral results showed that the MS group exhibited general slowing, suggesting impairment in alerting and orienting networks, as has been previously described in other studies. Time–frequency analysis of EEG revealed that the gamma band was related to the spatial translation of the attentional focus, and the alpha band seemed to be related to the expectancy mechanisms and cognitive processing of the target. Moreover, phase and nonphase modulations differed in their psychophysiological roles and were affected differently in the MS and HC groups. In summary, nonphase modulations can unveil hidden cognitive mechanisms for phase analysis and complete our knowledge of the neural basis of cognitive impairment in multiple sclerosis pathology.

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Section: Discussionmentioning

confidence: 99%

Altered phase and nonphase EEG activity expose impaired maintenance of a spatial-object attentional focus in multiple sclerosis patients

Vázquez‐Marrufo

Sarrias-Arrabal

Martı́n-Clemente

et al. 2020

Sci Rep

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“…This hypothesis is corroborated by previous findings that indicated people with lower education to be less used to applying cognitive strategies [55] resulting in being more prone to cognitive fatigue. However, the association between fatigue and cognitive performance related to attention functioning, assessed with PASAT‐3, was not significant, highlighting how cognitive fatigue is independent of fatigability [56–58] induced by the task [59]. Moreover, fatigue appears to be independent of cognitive dysfunction; indeed, although it can occur at any stage of the disease, it is often already present at onset in patients without cognitive impairment and with low disability [60].…”

Section: Discussionmentioning

confidence: 99%

Fatigue in multiple sclerosis patients with different clinical phenotypes: a clinical and magnetic resonance imaging study

Marchesi

Vizzino

Meani

et al. 2020

Euro J of Neurology

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Background and purpose The prevalence of fatigue and its relation with clinical, neuropsychological and brain magnetic resonance imaging (MRI) variables in a large cohort of multiple sclerosis (MS) patients was investigated. Method The Modified Fatigue Impact Scale and its subdomains were collected from 725 healthy controls and 366 MS patients [238 relapsing–remitting (RRMS) and 128 progressive (PMS)]. For the Modified Fatigue Impact Scale global and subdomains, MS patients were classified as fatigued (F‐MS) or non‐fatigued (NF‐MS) according to cut‐off values provided by logistic regression models with a specificity of 90% (i.e. a 10% false‐positive rate in classifying healthy controls). MS patients underwent neurological, neuropsychological and MRI evaluations. Clinical and MRI measures were compared between F‐MS and NF‐MS patients using age‐, sex‐ and phenotype‐adjusted linear models. Heterogeneities between phenotypes were tested with specific interaction terms. Results Global fatigue affected 174 (47.5%) MS patients, being more prevalent in PMS (PMS 64.1% vs. RRMS 38.7%, P < 0.001). For all dichotomizations, F‐MS were older (P from <0.001 to 0.012) and more depressed (P < 0.001) than NF‐MS patients. Compared to NF‐MS, cognitive F‐MS patients had lower education (P = 0.035). Compared to NF‐MS, patients with global and physical fatigue had higher Expanded Disability Status Scale only for RRMS (P < 0.001). Only RRMS patients with physical fatigue had lower brain (P = 0.05), white matter (P = 0.039) and thalamic volumes (P = 0.022) compared to NF‐MS patients. Conclusions In MS, fatigue is associated with older age, lower education and higher depression. Only in RRMS, fatigue is associated with Expanded Disability Status Scale and brain atrophy. A plateauing effect of disability and structural damage can explain the lack of associations in PMS.

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“…An increasing drive to examine cognitive performance fatigability in MS has demonstrated that people with MS are vulnerable to cognitive performance change (Berard et al , 2018, Cehelyk et al , 2018, Claros-Salinas et al , 2013, Wolkorte et al , 2015. However, similarly to our understanding of perceived fatigue, the factors influencing cognitive performance change remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Perceived fatigue and cognitive performance change in multiple sclerosis: Uncovering predictors beyond baseline fatigue

Muhlert

Robertson

et al. 2019

Multiple Sclerosis and Related Disorders

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A Longitudinal Evaluation of Cognitive Fatigue on a Task of Sustained Attention in Early Relapsing-Remitting Multiple Sclerosis

Cited by 25 publications

References 33 publications

Altered phase and nonphase EEG activity expose impaired maintenance of a spatial-object attentional focus in multiple sclerosis patients

Altered phase and nonphase EEG activity expose impaired maintenance of a spatial-object attentional focus in multiple sclerosis patients

Fatigue in multiple sclerosis patients with different clinical phenotypes: a clinical and magnetic resonance imaging study

Perceived fatigue and cognitive performance change in multiple sclerosis: Uncovering predictors beyond baseline fatigue

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