A longitudinal study of auditory evoked field and language development in young children

Yoshimura, Yuko; Kikuchi, Mitsuru; Ueno, Sanae; Shitamichi, Kiyomi; Remijn, Gerard B.; Hiraishi, Hirotoshi; Hasegawa, Chiaki; Furutani, Naoki; Oi, Manabu; Munesue, Toshio; Tsubokawa, Tsunehisa; Higashida, Haruhiro; Minabe, Yoshio

doi:10.1016/j.neuroimage.2014.07.034

Cited by 32 publications

(51 citation statements)

References 33 publications

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“…MEG recording conditions were similar to those reported in previous studies (Kikuchi et al, 2013; Yoshimura et al, 2014; Hasegawa et al, 2016). The cortical responses to finger movement were measured using a whole-head 151 channel MEG system for children (PQ 1151 R, Yokogawa/KIT), located in the MEG Center of Ricoh in a magnetically shielded room.…”

Section: Methodssupporting

confidence: 79%

Altered Gamma Oscillations during Motor Control in Children with Autism Spectrum Disorder

Ikeda

Yoshimura

et al. 2018

J. Neurosci.

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Autism is hypothesized to result in a cortical excitatory and inhibitory imbalance driven by inhibitory interneuron dysfunction, which is associated with the generation of gamma oscillations. On the other hand, impaired motor control has been widely reported in autism. However, no study has focused on the gamma oscillations during motor control in autism. In the present study, we investigated the motor-related gamma oscillations in autism using magnetoencephalography. Magnetoencephalographic signals were recorded from 14 right-handed human children with autism (5 female), aged 5–7 years, and age- and IQ-matched 15 typically developing children during a motor task using their right index finger. Consistent with previous studies, the autism group showed a significantly longer button response time and reduced amplitude of motor-evoked magnetic fields. We observed that the autism group exhibited a low peak frequency of motor-related gamma oscillations from the contralateral primary motor cortex, and these were associated with the severity of autism symptoms. The autism group showed a reduced power of motor-related gamma oscillations in the bilateral primary motor cortex. A linear discriminant analysis using the button response time and gamma oscillations showed a high classification performance (86.2% accuracy). The alterations of the gamma oscillations in autism might reflect the cortical excitatory and inhibitory imbalance. Our findings provide an important clue into the behavioral and neurophysiological alterations in autism and a potential biomarker for autism.SIGNIFICANCE STATEMENT Currently, the diagnosis of autism has been based on behavioral assessments, and a crucial issue in the diagnosis of autism is to identify objective and quantifiable clinical biomarkers. A key hypothesis of the neurophysiology of autism is an excitatory and inhibitory imbalance in the brain, which is associated with the generation of gamma oscillations. On the other hand, motor deficits have also been widely reported in autism. This is the first study to demonstrate low motor performance and altered motor-related gamma oscillations in autism, reflecting a brain excitatory and inhibitory imbalance. Using these behavioral and neurophysiological parameters, we classified autism and control group with good accuracy. This work provides important information on behavioral and neurophysiological alterations in patients with autism.

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Section: Methodssupporting

confidence: 79%

Altered Gamma Oscillations during Motor Control in Children with Autism Spectrum Disorder

Ikeda

Yoshimura

et al. 2018

J. Neurosci.

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“…Furthermore, an increase of P1m magnitude after a phonological intervention program has been reported in 6‐ to 7‐year‐old preschool children diagnosed with specific language impairment . Intriguingly, our recent studies have demonstrated that the magnitude of the P1m component in the left hemisphere is positively correlated with language performance in young preschool children (2–5 years old) even after controlling for confounding factors (e.g., age) . Regarding the developmental trajectory of the P1 component, one important previous EEG study has demonstrated a gradual decrease in the amplitude of the P1 evoked by contralateral ear stimulation with age, whereas the P1 amplitude evoked by ipsilateral ear stimulation is fairly constant up to age 10 and then decreases .…”

Section: Aef and Aep Studies In Children With Asdmentioning

confidence: 69%

“…Until 2010, MEG studies of neurodevelopmental disorders were rarely focused on children under 6 years old, whose heads were too small for whole‐head MEG systems. As shown in Figures and , after the development of the custom child‐sized MEG in 2010, researchers could focus on brain activity in young children (e.g., 3–7 years old), which had been the missing link in brain‐developmental neurophysiological data. Furthermore, in 2014, a novel whole‐head infant MEG system was developed .…”

Section: Magnetoencephalography In Young Childrenmentioning

confidence: 99%

“…69 Intriguingly, our recent studies have demonstrated that the magnitude of the P1m component in the left hemisphere is positively correlated with language performance in young preschool children (2-5 years old) even after controlling for confounding factors (e.g., age). 6,8 Regarding the developmental trajectory of the P1 component, one important previous EEG study has demonstrated a gradual decrease in the amplitude of the P1 evoked 48 8-32 14/10 † † MMF ‡ Auditory system † Data were available. ‡ A significant difference was found between ASD and HC.…”

Section: Aef and Aep Studies In Children With Asdmentioning

confidence: 99%

“…In the clinical setting, MEG is approved for use as part of a non-invasive pre-surgical evaluation for epilepsy surgery in children 12,13 as well as adults. During the past decade, in addition to its role in epilepsy, MEG has emerged as an important investigatory tool in neurodevelopmental studies of infants and young children regardless of their typical 6,8,[14][15][16][17][18][19][20][21] or atypical development. Conventional whole-head MEG systems have fixed sensor arrays designed to accommodate most adult heads.…”

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confidence: 99%

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Magnetoencephalography in the study of children with autism spectrum disorder

Kikuchi

Yoshimura

Mutou

et al. 2015

Psychiatry Clin Neurosci

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Magnetoencephalography (MEG) is a non-invasiveneuroimaging technique that provides a measure of cortical neural activity on a millisecond timescale with high spatial resolution. MEG has been clinically applied to various neurological diseases, including epilepsy and cognitive dysfunction. In the past decade, MEG has also emerged as an important investigatory tool in neurodevelopmental studies. It is therefore an opportune time to review how MEG is able to contribute to the study of atypical brain development. We limit this review to autism spectrum disorder (ASD). The relevant published work for children was accessed using PubMed on 5 January 2015. Case reports, case series, and papers on epilepsy were excluded. Owing to their accurate separation of brain activity in the right and left hemispheres and the higher accuracy of source localization, MEG studies have added new information related to auditoryevoked brain responses to findings from previous electroencephalography studies of children with ASD. In addition, evidence of atypical brain connectivity in children with ASD has accumulated over the past decade. MEG is well suited for the study of neural activity with high time resolution even in young children. Although further studies are still necessary, the detailed findings provided by neuroimaging methods may aid clinical diagnosis and even contribute to the refinement of diagnostic categories for neurodevelopmental disorders in the future.Key words: auditory-evoked field, autism spectrum disorder, connectivity, magnetoencephalography, young children. MAGNETOENCEPHALOGRAPHY IN YOUNG CHILDRENM AGNETOENCEPHALOGRAPHY (MEG) AND electroencephalography (EEG) are non-invasive methods for recording neural activity. Contrary to functional magnetic resonance imaging and singlephoton emission computed tomography, which measure a hemodynamic response linked to metabolic demand, MEG and EEG measure a direct consequence of the electrical activity of neurons. These two techniques have a temporal resolution of approximately 1 ms, which is the typical resolution of measurable electrical phenomena in the brain. These two techniques have advantages over other neuroimaging techniques for use in young children, including fewer constraints and the absence of radiation and unpleasant sounds.MEG has been in development for human use since the 1960s, and its development has been greatly

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Atypical development of the central auditory system in young children with Autism spectrum disorder

et al. 2016

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The P1m component of the auditory evoked magnetic field is the earliest cortical response associated with language acquisition. However, the growth curve of the P1m component is unknown in both typically developing (TD) and atypically developing children. The aim of this study is to clarify the developmental pattern of this component when evoked by binaural human voice stimulation using child-customized magnetoencephalography. A total of 35 young TD children (32-121 months of age) and 35 children with autism spectrum disorder (ASD) (38-111 months of age) participated in this study. This is the first report to demonstrate an inverted U-shaped growth curve for the P1m dipole intensity in the left hemisphere in TD children. In addition, our results revealed a more diversified age-related distribution of auditory brain responses in 3- to 9-year-old children with ASD. These results demonstrate the diversified growth curve of the P1m component in ASD during young childhood, which is a crucial period for first language acquisition. Autism Res 2016, 9: 1216-1226. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

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A longitudinal study of auditory evoked field and language development in young children

Cited by 32 publications

References 33 publications

Altered Gamma Oscillations during Motor Control in Children with Autism Spectrum Disorder

Altered Gamma Oscillations during Motor Control in Children with Autism Spectrum Disorder

Magnetoencephalography in the study of children with autism spectrum disorder

Atypical development of the central auditory system in young children with Autism spectrum disorder

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