A longitudinal study of dentine lead levels and intelligence, School performance and behaviour: The measurement of dentine lead

Fergusson, J. E.; Kinzett, Nicola G.; Fergusson, David M.; Horwood, L. John

doi:10.1016/0048-9697(89)90079-x

Cited by 33 publications

(44 citation statements)

References 41 publications

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“…In the cross-sectional study in Scotland (38), deficits in number skills and reading were found in addition to deficits in IQ. In the New Zealand prospective study (60)(61)(62), robust deficits in school performance including reading, math, spelling, and handwriting, as assessed by the teachers, were present in the absence of deficits in IQ, as measured by the WISC-R when the children were 9 years old. At 8 to 12 years of age, these children exhibited significant impairment in word recognition correlated to dentine lead levels at 6 to 7 years of age (63).…”

Section: Human Studiesmentioning

confidence: 99%

Behavioral effects of lead: commonalities between experimental and epidemiologic data.

Rice

1996

Environ Health Perspect

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Section: Human Studiesmentioning

confidence: 99%

Behavioral effects of lead: commonalities between experimental and epidemiologic data.

Rice

1996

Environ Health Perspect

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“…(73). Lead exposure is a potent predictor of behaviors linked with delinquency and criminality, such as impulsivity, hyperactivity, and aggressive behaviors (29,41,73,122). In experiments with rodents and nonhuman primates, early lead exposure caused abnormal mother-infant interactions, higher rates of antagonistic interactions, and reduced social play (32,71).…”

Section: Antisocial Behaviorsmentioning

confidence: 99%

The Impact of Toxins on the Developing Brain

Lanphear

2015

Annu. Rev. Public Health

150

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The impact of toxins on the developing brain is usually subtle for an individual child, but the damage can be substantial at the population level. Numerous challenges must be addressed to definitively test the impact of toxins on brain development in children: We must quantify exposure using a biologic marker or pollutant; account for an ever-expanding set of potential confounders; identify critical windows of vulnerability; and repeatedly examine the association of biologic markers of toxins with intellectual abilities, behaviors, and brain function in distinct cohorts. Despite these challenges, numerous toxins have been implicated in the development of intellectual deficits and mental disorders in children. Yet, too little has been done to protect children from these ubiquitous but insidious toxins. The objective of this review is to provide an overview on the population impact of toxins on the developing brain and describe implications for public health.

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“…Neighborhood residents welcomed additional studies of the effects of lead on their children. A review of the literature at that time suggested that children experience a one -to three -point (Winneke et al, 1996 ) to a four-to six -point deficit in IQ per 10 g/dl increase in lead burden ( Smith, 1989 ) , as well as a variety of school -performance problems ( Yule et al, 1981;Bellinger et al, 1986;Fulton et al, 1987;Fergusson et al, 1988;Munoz et al, 1993 ). We believe that the construct of IQ is not particularly helpful in understanding lead's neurotoxic effects.…”

Section: Project Backgroundmentioning

confidence: 99%

Measuring developmental outcomes of lead exposure in an urban neighborhood: the challenges of community-based research

Jordan

Lee

Shapiro

2000

J Expo Sci Environ Epidemiol

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The Developmental Research on Attention and Memory Skills ( DREAMS ) Project measures developmental outcomes of approximately 330 children at risk for lead exposure within an ethnically diverse, inner -city neighborhood. This study is one project of the Phillips Neighborhood Healthy Housing Collaborative, a 6 -year -old collaboration between residents of the Phillips community in Minneapolis, university researchers, and representatives of various public and private agencies. Our experience carrying out this research is used to highlight both the benefits of, and the challenges to, measuring exposure outcomes in inner -city children using a community -based research approach. Challenges to working within a community collaborative, to studying an ethnically diverse and economically disadvantaged neighborhood, and to utilizing neighborhood residents as project staff are discussed. The strategies used to address these issues are presented to offer ideas for surmounting the challenges inherent in community -based research. The investigation of community environmental health problems through a community -based research approach can result in improved methodology, enhanced quality of data collected, and increased effectiveness of data dissemination. In addition, it can lead to important findings that inform the scientific community and create positive community changes. It is paramount, however, that potential obstacles be anticipated and planned for, or else be detected early and promptly responded to, in a manner that preserves scientific rigor while respecting community needs and values. Journal of Exposure Analysis and Environmental Epidemiology ( 2000 ) 10, 732 ± 742.

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A longitudinal study of dentine lead levels and intelligence, School performance and behaviour: The measurement of dentine lead

Cited by 33 publications

References 41 publications

Behavioral effects of lead: commonalities between experimental and epidemiologic data.

Behavioral effects of lead: commonalities between experimental and epidemiologic data.

The Impact of Toxins on the Developing Brain

Measuring developmental outcomes of lead exposure in an urban neighborhood: the challenges of community-based research

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