A longitudinal study of gastrointestinal diseases in individuals diagnosed with infantile autism as children

Mouridsen, Svend Erik; Rich, Bente; Isager, Torben

doi:10.1111/j.1365-2214.2009.01021.x

Cited by 28 publications

(22 citation statements)

References 29 publications

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“…In a cross-sectional study comparing lifetime prevalence of GI symptoms in 50 ASD children with age/sex and ethnicity matched normal controls and children with developmental disabilities, 70% of ASD children had a history of GI [Mouridsen et al, 2009]. Thus, whilst GI symptoms in ASD are a common complaint it is not clear that their prevalence exceeds that of the general population.…”

Section: Gastrointestinal Diseasementioning

confidence: 88%

Autism and mitochondrial disease

Haas

2010

Dev Disabil Res Revs

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Autism spectrum disorder (ASD) as defined by the revised Diagnostic and Statistical Manual of Mental Disorders: DSM IVTR criteria (American Psychiatric Association [2000] Washington, DC: American Psychiatric Publishing) as impairment before the age of 3 in language development and socialization with the development of repetitive behaviors, appears to be increased in incidence and prevalence. Similarly, mitochondrial disorders are increasingly recognized. Although overlap between these disorders is to be expected, accumulating clinical, genetic, and biochemical evidence suggests that mitochondrial dysfunction in ASD is more commonly seen than expected. Some patients with ASD phenotypes clearly have genetic-based primary mitochondrial disease. This review will examine the data linking autism and mitochondria.

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Section: Gastrointestinal Diseasementioning

confidence: 88%

Autism and mitochondrial disease

Haas

2010

Dev Disabil Res Revs

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“…Research designs included prospective studies (53%), as well as studies mining existing databases [33][34][35][36] or medical charts. [37][38][39] In terms of confirming diagnostic status, 3 studies (20%) used either the ADI-R or ADOS; 3 (20%) used the CARS. Six (40%) relied exclusively on chart review or clinical provider, 1 study (7%) involved parent report, and the remaining 2 studies (13%) did not identify the source of ASD diagnosis.…”

Section: Characteristics Of Studies and Participantsmentioning

confidence: 99%

“…Diarrhea was the most common symptom assessed, followed by general GI concerns. This latter category primarily involved denoting the percentage of children experiencing $1 GI clinical element based on a composite of possible symptoms 23,33,[36][37][38][39][40][41] ; 3 studies broadly asked caregivers whether there were concerns about their child' s bowels, 42 whether their child experienced chronic or ongoing GI problems, 23 or whether their child had a history of GI dysfunction. 43 Nine studies (60%) included information outside the core symptoms captured by our coding sheet, such as recurrent fever, 39 feeding or dietary concerns, 37,41,42 or behavioral concerns (eg, sleep, sudden aggressive behavior) 40 or simply included a broad category of "other GI problems."…”

Section: Characteristics Of Studies and Participantsmentioning

confidence: 99%

“…All studies reported information on age (ie, mean, SD, range). Two studies 37,38 involved a longitudinal design assessing the incidence of GI symptoms at fixed time periods; both also presented an overall composite of symptoms, which was used for the current analysis. Eight studies (53%) reported matching or statistical equivalence for age across groups; 4 (27%) noted equivalence in the proportion of boys to girls.…”

Section: Characteristics Of Studies and Participantsmentioning

confidence: 99%

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Gastrointestinal Symptoms in Autism Spectrum Disorder: A Meta-analysis

et al. 2014

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BACKGROUND:In pediatric settings, parents often raise concerns about possible gastrointestinal (GI) symptoms in autism spectrum disorder (ASD), yet the specificity of these concerns are not well studied. OBJECTIVE:To conduct a meta-analysis of research investigating GI symptoms among children with ASD. METHODS:We searched Medline, PsycINFO, and PubMed databases in peer-reviewed journals. Analysis involved studies with a comparison group presenting quantitative data on GI symptoms using combinations of terms for ASD and GI indicators. The systematic search yielded 15 studies. We calculated effect sizes and 95% confidence intervals (CIs) using a random-effects model. RESULTS:Children with ASD experience significantly more general GI symptoms than comparison groups, with a standardized mean difference of 0.82 (0.24) and a corresponding odds ratio (OR) of 4.42 (95% CI, 1.90-10.28). Analysis also indicated higher rates of diarrhea (OR, 3.63; 95% CI, 1.82-7.23), constipation (OR, 3.86; 95% CI, 2.23-6.71), and abdominal pain (OR, 2.45; 95% CI, 1.19-5.07). CONCLUSIONS:Results indicate greater prevalence of GI symptoms among children with ASD compared with control children. Identified studies involved high methodological variability and lack of comprehensive data prohibited analysis of GI pathophysiologies (eg, gastroesophageal reflux) typically associated with organic etiologies, limiting conclusions about the underpinnings of the observed association. Future research must address critical questions about the causes and long-term impact of GI symptoms in ASD. Such analyses will require more systematic research and clinical activities, including improved diagnostic screening, standardized assessment, and exploration of potential moderators (eg, dietary restrictions).

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“…The reported prevalence of gastrointestinal problems in children with ASD has ranged from 9 to 91 % Ming et al 2008;Black et al 2002;Fombonne and Chakrabarti 2001;Ibrahim et al 2009;Molloy and Manning-Courtney 2003;Mouridsen et al 2010;Nikolov et al 2009;Taylor et al 2002;Valicenti-McDermott et al 2008;Horvath and Perman 2002;Wang et al 2011;Parracho et al 2005;Smith et al 2009). Wang et al (2011) commented on the factors that lead to differing rates of GI symptoms across studies.…”

Section: Prevalencementioning

confidence: 99%

Gastrointestinal Symptoms in Autism Spectrum Disorder: A Literature Review

Mannion

Leader

2013

Rev J Autism Dev Disord

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The purpose of this literature review was to provide an overview of the research on gastrointestinal (GI) symptoms in autism spectrum disorder. Topics explored include the prevalence of GI symptoms, the importance of studying GI symptoms, the difficulties in diagnosis, as well as the questionnaire measures used to assess gastrointestinal symptoms. Research on the relationships between gastrointestinal symptoms and developmental regression, language and communication, autism severity, challenging behavior, comorbid psychopathology, sleep problems, and sensory issues is also discussed. The use of special diets is discussed also. Finally, recommendations for treatment are given as well as areas where future research is needed.

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A longitudinal study of gastrointestinal diseases in individuals diagnosed with infantile autism as children

Abstract: Overall, no evidence was found that patients with IA were more likely than control persons without IA to have defined GI diseases during the 30.3-year observation period.

Cited by 28 publications

References 29 publications

Autism and mitochondrial disease

Autism and mitochondrial disease

Gastrointestinal Symptoms in Autism Spectrum Disorder: A Meta-analysis

Gastrointestinal Symptoms in Autism Spectrum Disorder: A Literature Review

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