A Love-wave biosensor using nucleic acids as ligands

Schlensog, Marc Dominic

doi:10.1016/s0925-4005(04)00149-2

Cited by 36 publications

(52 citation statements)

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“…A low-wave acoustic sensor (Schlensog et al, 2004) was used to detect the interaction of thrombin with RNA and DNA aptamers (Gronewold et al, 2005). The authors compared the binding of the thrombin to RNA aptamer using a filter binding method utilizing radiolabeling of RNA aptamer by 3 -32 P and also by using the SPR method.…”

Section: Acoustic Methodsmentioning

confidence: 99%

Detection of Protein–Aptamer Interactions by Means of Electrochemical Indicators and Transverse Shear Mode Method

Hianik

2008

Aptamers in Bioanalysis

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Section: Acoustic Methodsmentioning

confidence: 99%

Detection of Protein–Aptamer Interactions by Means of Electrochemical Indicators and Transverse Shear Mode Method

Hianik

2008

Aptamers in Bioanalysis

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“…The 15-mer TBA sequence was identified by SELEX as the minimal consensus sequence (5'-GGTTGGTGTGGTTGG-3') from a pool of ~10 13 96-mer oligonucleotides containing a randomised 60-mer sequence (21). The crystal structure of the complex thrombin-TBA was solved by X-Ray crystallography (22 (16,(23)(24)(25)(26)(27)(28)(29)(30)(31).…”

Section: Introductionmentioning

confidence: 99%

Selection of thrombin-binding aptamers by using computational approach for aptasensor application

Bini

Mascini

et al. 2011

Biosensors and Bioelectronics

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“…An enhancement in device sensitivity can therefore be achieved, with Love waves offering one of the highest mass sensitivities. Love wave sensors have been used for a variety of applications including the detection of biological analytes [4,5] liquid properties [6,7] and evaporation kinetics [8].…”

Section: Introductionmentioning

confidence: 99%

SU-8 Guiding Layer for Love Wave Devices

Roach

Atherton

Doy

et al. 2007

Sensors

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SU-8 is a technologically important photoresist used extensively for the fabrication of microfluidics and MEMS, allowing high aspect ratio structures to be produced. In this work we report the use of SU-8 as a Love wave sensor guiding layer which allows the possibility of integrating a guiding layer with flow cell during fabrication. Devices were fabricated on ST-cut quartz substrates with a single-single finger design such that a surface skimming bulk wave (SSBW) at 97.4 MHz was excited. SU-8 polymer layers were successively built up by spin coating and spectra recorded at each stage; showing a frequency decrease with increasing guiding layer thickness. The insertion loss and frequency dependence as a function of guiding layer thickness was investigated over the first Love wave mode. Mass loading sensitivity of the resultant Love wave devices was investigated by deposition of multiple gold layers. Liquid sensing using these devices was also demonstrated; water-glycerol mixtures were used to demonstrate sensing of densityviscosity and the physical adsorption and removal of protein was also assessed using albumin and fibrinogen as model proteins.

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A Love-wave biosensor using nucleic acids as ligands

Cited by 36 publications

References 0 publications

Detection of Protein–Aptamer Interactions by Means of Electrochemical Indicators and Transverse Shear Mode Method

Detection of Protein–Aptamer Interactions by Means of Electrochemical Indicators and Transverse Shear Mode Method

Selection of thrombin-binding aptamers by using computational approach for aptasensor application

SU-8 Guiding Layer for Love Wave Devices

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