A Low Molecular Weight Polypeptide Which Accumulates upon Inhibition of Porphyrin Biosynthesis in Maize

Schuster, Ayelet; Harel, E.

doi:10.1104/pp.77.3.648

Cited by 1 publication

(1 citation statement)

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“…In our study, we aimed to model a treatment strategy in which the virulence of acne-associated strains is targeted without disrupting the growth of health-associated strains. Other compounds, such as 4,6-dioxoheptanoic acid and isonicotinic acid hydrazide, also inhibit porphobilinogen synthase ( 49 , 50 ) and can potentially be used to inhibit porphyrin biosynthesis. LA and other related small molecules that inhibit porphyrin biosynthesis in P. acnes are attractive drug candidates for the treatment of acne.…”

Section: Discussionmentioning

confidence: 99%

Strain-Level Differences in Porphyrin Production and Regulation in Propionibacterium acnes Elucidate Disease Associations

Johnson

Kang

Barnard

et al. 2016

mSphere

100

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Propionibacterium acnes is a dominant bacterium residing on skin, and it has been thought to play a causal role in several diseases including acne, a common skin disease affecting more than 80% of people worldwide. While specific strains of P. acnes have been associated with either disease or healthy skin, the mechanisms remain unclear. Recently, we showed that vitamin B12 supplementation increased porphyrin production in P. acnes, leading to acne development (D. Kang, B. Shi, M. C. Erfe, N. Craft, and H. Li, Sci. Transl. Med. 7:293ra103, 2015, doi:10.1126/scitranslmed.aab2009). Here, we reveal that the levels of porphyrin production and vitamin B12 regulation are different between acne- and health-associated strains, suggesting a potential molecular mechanism for disease-associated strains in acne pathogenesis and for health-associated strains in skin health. This study highlights the importance of understanding the strain-level differences of the human microbiota in disease pathogenesis. Our findings also suggest the porphyrin biosynthesis pathway as a candidate drug target and use of health-associated strains as potential probiotics in novel acne therapeutics.

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Section: Discussionmentioning

confidence: 99%