We present a novel switched-capacitor, integrator-multiplexing, second-order delta-sigma modulator (DSM) featuring a single differential difference amplifier (DDA). Power consumption is low and resolution is high when this DSM is used for portable electroencephalographic applications. A single DDA (rather than a conventional operational transconductance amplifier) with appropriate switch and capacitor architectures is used to create the second-order switched-capacitor DSM. The configuration ensures that the resolution is high. The modulator was implemented using a standard 180[Formula: see text]nm complementary metal–oxide–silicon process. At a supply voltage of 1.8[Formula: see text]V, a signal bandwidth of 250[Formula: see text]Hz and a sampling frequency of 200[Formula: see text]kHz, simulations demonstrated that the modulator achieved an 82[Formula: see text]dB peak signal-to-noise–distortion ratio and an effective number of bits of 14.