“…Generally, pH-sensitive polymers, including weak acidic and basic groups that act as poly-electrolytes, are employed. These polymers can be derived from both natural sources (chitosan, gelatin, protein, starch, and cellulose derivatives) [73][74][75][76][77] or synthetic routes (polyanhydrides, α-hydroxy acids, esters, anhydrides, acetals, carbonates, amides, urethanes, phosphates, poly(D,L-lactic acid) (PDLLA), polylactic acid (PLA) (both L-and D, L-lactide forms), poly(glycolic acid) (PGA), and poly(lactic-coglycolic acid) (PLGA)) [78,79]. Numerous pH-sensitive polymeric NPs have been prepared including chitosan, polyanions, a mixture of them, and also cross-linked polymers (nanogels) [80,81].…”