The energy consumption of mechanical ventilation in buildings needs to be reduced. An efficient way to achieve this goal is to reduce the hydraulic resistance of the ventilation duct system elements, for example, that of sudden expansions. Ventilation ducts and pipe fittings are frequently of rectangular cross-section. The present paper investigates a passive flow control method in order to reduce the loss coefficient of a square-to-square sudden expansion, where the loss-reducing appendages are short guide vanes, termed as miniflaps, placed at the step edge of the sudden expansion. The turbulent flow is examined numerically using the generalized k-ω model of the Ansys Fluent software for different area ratios of the sudden expansion, miniflap lengths, and miniflap angle setups. The Reynolds number is kept constant at 1.08·105. Based on the results of the numerical simulations, the loss coefficient of the sudden expansion can be reduced by ~20–25% for an optimum miniflap angle between 9° and 12°. Increasing the length of the miniflaps leads to a greater reduction of the loss coefficient up to a miniflap length of 0.3 dh1, where dh1 is the upstream hydraulic diameter of the duct.