Given an irreducible, end‐periodic homeomorphism f:S→S$f: S \rightarrow S$ of a surface with finitely many ends, all accumulated by genus, the mapping torus, Mf$M_f$, is the interior of a compact, irreducible, atoroidal 3‐manifold M¯f$\overline{M}_f$ with incompressible boundary. Our main result is an upper bound on the infimal hyperbolic volume of M¯f$\overline{M}_f$ in terms of the translation length of f$f$ on the pants graph of S$S$. This builds on work of Brock and Agol in the finite‐type setting. We also construct a broad class of examples of irreducible, end‐periodic homeomorphisms and use them to show that our bound is asymptotically sharp.