A Lymphoblastoma Occurring in Young Chicks Reared on a Diet Treated with Ferric Chloride to Destroy Vitamin E

Some Aspects of Vitamin E in the Expression of Biological Information*

“…Within 15 minutes after administration of the isotope and vitamin E, there is an increase in the amount of W-labeled RNA above that of the controls, while untreated vitamin E-deficient animals exhibit levels below those of the controls. The data plotted in FIGURE 4 show that the level of I4C-labeled nuclear RNA remains elevated up to one hour after the injection of vitamin E, and then returns to normal. In vitamin E-deficient animals, the I4C-labeled RNA levels continue to rise for up to two hours before a decline is observed.…”

Effect of avitaminosis E on reproduction and vitamin E storage in the tissues and milk of goats

“…approximately the same period of time to baBal ration ?I which contained no lard, 15 rats had normal litters at term. She negative control rats all resor'bed their young.The results shown in tahle3 in agreement with those of workers previously cited and with results obtained in trials in this experiment (cf, tables h aai 5) that lard and perhaps cod liver oil contain vitamin jB-destroying substances. Cod liver oil, however, is retained in ration VI, since it is inqjortant to inclxsde certain \in8aturated fatty acids in the diet without which gestation is Tjneruccessful (iivans, Lepkovsky and Murphy(75)) or testicular degeneration occurs (Svans, Lepkovsky and Murphy (76)).…”

Wheat Germ Oil in the Control of Fowl Paralysis

“…A similar E deficient diet fed to laying females, according to Adamstone (1931), affects the chick embryo, leading to vascular degeneration, and by the fourth day of incubation to a mesodermal cellular reaction which, like a "lethal ring," chokes off the blood supply and causes death of the embryo.…”

“…Adamstone (1936) reported the occurrence of a "lymphoblastoma"-like condition resembling fowl leukosis in young birds kept on a ferric chloride treated diet. The pathologic process, however, was initiated by degenerative changes, and the observed cellular proliferation seemed to be reactive and secondary in character.…”