A

Elks, J.; Ganellin, C. Robin

doi:10.1007/978-1-4757-2085-3_1

Cited by 6 publications

(1 citation statement)

References 1,439 publications

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“…Amcinonide is a corticosteroid applied as an antiinflammatory agent [1]. It is used in different pharmaceutical preparations such as film-forming creams, lotions and ointments for the treatment of skin disorders [2].…”

Section: Introductionmentioning

confidence: 99%

High-Performance Liquid Chromatographic Quantitative Determination of Amcinonide and Benzyl Alcohol in Pharmaceutical Preparations

Khan¹,

Khan²,

Perveen³

et al. 2008

TOACJ

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This paper describes a simple, precise, and validated high-performance liquid chromatographic method for the simultaneous quantitative determination of amcinonide and benzyl alcohol in pharmaceutical preparations. The separation was achieved using a Zorbax reversed-phase column (5 m, 250x4.6mm) at room temperature with an isocratic mixture of deionized water and acetonitrile (70:30 v/v) at a flow rate of 1.5ml/min and detection at 254 nm. The limits of quantification for amcinonide and benzyl alcohol were found to be 4-30 g/ml and 80-600 g/ml, respectively. The validity of the method was evaluated in terms of linear regression analysis, precision, specificity, accuracy and ruggedness. The developed methodology is an economic, time-saving, straight forward and precise assay for the determination of amcinonide and benzyl alcohol in pharmaceutical preparations. It can be readily utilized for quality assurance and R&D laboratories of pharmaceutical and cosmetic industry.

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Section: Introductionmentioning

confidence: 99%