A macrophage defect in women with recurrent Candida vaginitis and its reversal in vitro by prostaglandin inhibitors

Witkin, SS; Hirsch, James G.; Ledger, W. A.

doi:10.1016/0020-7292(87)90378-x

Cited by 21 publications

(44 citation statements)

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“…PBMC of patients with RVVC in acute phase was found not to respond with proliferation to Candida antigen in comparison to the remission and control groups. Similar results were obtained by other authors [8,9,12,13]. Some explanation for the lack of responsiveness seems to be present in Witkin et al's work [12].…”

Section: Discussionsupporting

confidence: 90%

“…The results presented by us con¢rmed the data of others [8,9,12,13], that in RVVC patients, suppression of CMIR occurs, measured by both proliferation and cytokine secretion. The reason for this suppression remains unknown.…”

Section: Discussionsupporting

confidence: 89%

“…Similar results were obtained by other authors [8,9,12,13]. Some explanation for the lack of responsiveness seems to be present in Witkin et al's work [12]. They indicated that macrophages from patients with RVVC produce prostaglandin, which may suppress proliferation.…”

Section: Discussionsupporting

confidence: 85%

“…Results of those studies carried out by di¡erent authors [8^13] are often contradictory. Some authors revealed the suppression of CMIR [8,9,12,13]. Others did not observe such suppression [10,11].…”

Section: Discussionmentioning

confidence: 97%

“…In the majority of cases, delayed skin reactivity to Candida antigens was found to be weakened [9,10]. Some authors also observed reduced lymphoproliferation after stimulation with yeasts in comparison to the control group [8,12,13], while others did not ¢nd such di¡erences [10,11]. Numerous multidirectional studies on the pathogenesis of recurrent vulvovaginal candidiasis have been carried out, but this problem has not yet been solved [1,2,4,6^17].…”

Section: Introductionmentioning

confidence: 99%

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The study of cell-mediated immune response in recurrent vulvovaginal candidiasis

Nawrot¹

2000

FEMS Immunology and Medical Microbiology

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The aim of this work was to examine in vitro the ability of cells from patients with recurrent vulvovaginal candidiasis (RVVC) to cell-mediated immune response. Peripheral blood mononuclear cells (PBMC) and whole blood cells (WBC) of 37 RVVC patients in acute infection and 14 in remission were examined for the ability to proliferation and cytokines production (IFN, TNF, IL-6). As a control, a group of 25 healthy women were examined. The cells were stimulated with Candida antigen (HKCA), LPS and PHA. To indicate the level of cytokines, the following cell-lines were used: A549 for IFN, WEHI 164 for TNF and 7TD1 for IL-6. The proliferation/death of cells was determined by colorimetric test using MTT. Distinct suppression of cell-mediated immune response (CMI) was shown in all patients comparing to the control. Greatest suppression was found in the acute phase of the disease. The ability of cells to proliferate and produce IFN increases only in remission. The data seem to suggest that in this phase of disease, the ability of cell-mediated immune response is restored. It was also indicated that IFN may take part in protection against Candida infection.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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The study of cell-mediated immune response in recurrent vulvovaginal candidiasis

Nawrot¹

2000

FEMS Immunology and Medical Microbiology

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The apparition macrophage and Döderlein bacillus is negatively correlated in class I Papanicolaou smear: A morphological examination

Ikegami

Watanabe

Kumagai

et al. 2020

Diagnostic Cytopathology

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Background: Nonspecific vaginitis, also known as Bacterial vaginosis, unlike genital candidiasis and trichomoniasis, is caused by microbiome breakdown. Döderlein's bacillus are gram-positive bacillus that form a microbiome, reproduce in the female vagina after gaining sexual maturity, secrete lactic acid, and prevent the growth of other vaginitis-causing bacteria. Clue cell are squamous epithelial cells with Gardnerella sp. attached to their cell surface. The presence of clue cell is one of the diagnostic criteria for nonspecific vaginitis. Additionally, although macrophages are reported to protect against candidal vaginitis, there are no reports of studies examining the association between macrophages and clue cell. Materials and Methods: After re-staining 300 class I specimens by cervical cancer screening with Papanicolaou staining, the appearance of Döderlein's bacillus, macrophages, and clue cell was observed. Result: Age group and appearance of Döderlein's bacillus were negatively correlated. The rate of appearance of macrophages was positively correlated with the age group. In people aged 50 years or more, the appearance rate of clue cells was significantly lower in the macrophage appearance group than that in the non-appearance group. Conclusion: This study suggested that macrophages, and not Döderlein's bacillus, may play an important role in defense against nonspecific vaginitis.

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Cellular immunity in recurrent vulvovaginal candidiasis

Corrigan¹,

Clancy

Dunkley

et al. 1998

Clinical and Experimental Immunology

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Impaired T cell function has been reported to predispose women to recurrent vulvovaginal candidiasis, but conflicting results have been noted in the literature. Most clinical episodes occur in the late luteal phase, suggesting hormonal influence on host resistance. The present study assesses the cellular immune responses of 28 women with recurrent vaginal candidiasis (patients) and 25 control women (controls), noting results in relation to whether the women were in the follicular or luteal phase of the menstrual cycle at the time of sampling. Candida-stimulated peripheral blood lymphocyte proliferation was significantly reduced in patients compared with controls. Interferon-gamma (IFN-gamma) production in response to both Candida and purified protein derivative (PPD) stimulation was significantly lower in patients compared with controls. Skin test responses were comparable in both groups. A significant reduction in Candida-stimulated IFN-gamma production was seen in patients but not controls in the follicular phase compared with those in the luteal phase. There was also a trend towards lower proliferation in response to Candida in patients but not controls in the follicular phase compared with patients in the luteal phase. These results suggest that there is a partial T cell dysregulation in recurrent vaginal candidiasis which may be exacerbated by the hormonal balance present during the follicular phase, correlating with the risk of clinical infection.

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A macrophage defect in women with recurrent Candida vaginitis and its reversal in vitro by prostaglandin inhibitors

Cited by 21 publications

References 0 publications

The study of cell-mediated immune response in recurrent vulvovaginal candidiasis

The study of cell-mediated immune response in recurrent vulvovaginal candidiasis

The apparition macrophage and Döderlein bacillus is negatively correlated in class I Papanicolaou smear: A morphological examination

Cellular immunity in recurrent vulvovaginal candidiasis

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