A Magnetic Nanoprobe Technology for Detecting Molecular Interactions in Live Cells

Abstract

when seasonality is accounted for, reasonable local temperature estimates can be drawn from the GRIP isotopic record; the correction due to source temperature changes is of lesser importance at glacial-interglacial scales than during rapid events. Moreover, the comparison between our estimate of DT source and available North Atlantic sediment-based SST reconstructions suggests that large changes in geographical moisture source location occur both at the orbital and millennial scales. We show that DT source reflects obliquity changes and that DT source and DT site are of opposite sign, both at orbital and millennial time scales. The influence of obliquity on deuterium excess and moisture origin, already identified for Antarctica, is confirmed for Greenland. When cold conditions prevail in the mid-and high latitudes, the moisture origin shifts to milder southward locations (5). Finally, we point to striking similarities between the calcium-dust records and the site-to-source temperature gradient; both are strongly modulated by obliquity, and the coupled climate model results suggest that obliquity could be linked with dust source areas through the land-sea temperature contrast. At the millennial time scale, the site-to-source temperature fluctuations highlight large-scale changes in atmospheric circulation, which is consistent with the observation of simultaneous rapid climate changes at polar, temperate, and tropical latitudes (40) also recorded in Greenland ice chemistry and methane fluctuations (41). Modeling studies have indeed shown that Northern Hemisphere storm tracks are influenced not only by the topography of the ice sheets but also by the sea-ice extent and the meridional temperature gradients (30).Such large changes in the atmospheric hydrological cycle and associated climate feedbacks are not fully represented in the intermediatecomplexity climate models commonly used to understand the mechanisms of abrupt events. Nonetheless, they could play a key role in the generation of instabilities of the ice sheets and the ocean circulation, amplified by changes in sea-ice extent, as has been suggested for the last glacial inception (42).

Nanoparticle-mediated signaling endosome localization regulates growth cone motility and neurite growth

“…At forces >15 pN, fMNPs changed from punctate to diffuse in neurites and growth cones, indicating we were unable to pull MNP signaling endosomes toward the magnet without disrupting their integrity (n = 5; Movie S4). Thus, we were unable to pull signaling endosomes toward the magnet without disrupting endosome integrity similar to results in nonneuronal cells (28). We did not further examine either the cellular or molecular effects induced by disrupting signaling endosome integrity.…”

Antibiotic mediated synthesis of gold nanoparticles with potent antimicrobial activity and their application in antimicrobial coatings

“…There is great interest in tailoring the size of nanomaterials to achieve unique chemical and physical properties with these materials having increasing importance in biological, [1][2][3] biomedical, 4,5 catalytic, 6,7 optoelectronic 8-10 and pharmaceutical 11,12 applications. For example, metal nanoparticles, magnetic nanoparticles and semiconductor quantum dots and their composite nanomaterials have been conjugated with small molecules such as DNA, drugs and proteins for delivery applications.…”

Dendrimer-Modified Magnetic Nanoparticles Enhance Efficiency of Gene Delivery System

“…For example, superparamagnetic iron oxide nanoparticles have been recognized as a promising tool for the site-specific delivery of drugs and diagnostics agents (5)(6)(7). Magnetic nanoparticles (MNP) have been widely explored to have potentials in applications, such as hyperthermia (8), magnetic resonance imaging contrast agent (9), tissue repair (10), immunoassay (11), drug/gene delivery (12), and cell separation (13).…”