A Marine-Derived Anti-Inflammatory Scaffold for Accelerating Skin Repair in Diabetic Mice

Huang, Xiaoli; Guan, Na; Li, Qiu

doi:10.3390/md19090496

Cited by 7 publications

(2 citation statements)

References 25 publications

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“…Topical application of BAP-PVA-based scaffolds accelerated DW healing within 12 days by promoting neo-vascularization, anti-inflammatory action, and cell proliferation at the site of injury. In addition, BAP-PVA-based scaffold-treated group exhibited 1.05-folds and 1.17-folds increase in wound closure in comparison to PVA alone treated mice and diabetic control groups [ 174 ].…”

Section: Materials Used In Scaffold Fabricationmentioning

confidence: 99%

Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds

Awasthi

Gulati

Kumar

et al. 2022

BioMed Research International

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Diabetic wound (DW) is a secondary application of uncontrolled diabetes and affects about 42.2% of diabetics. If the disease is left untreated/uncontrolled, then it may further lead to amputation of organs. In recent years, huge research has been done in the area of wound dressing to have a better maintenance of DW. These include gauze, films, foams or, hydrocolloid-based dressings as well as polysaccharide- and polymer-based dressings. In recent years, scaffolds have played major role as biomaterial for wound dressing due to its tissue regeneration properties as well as fluid absorption capacity. These are three-dimensional polymeric structures formed from polymers that help in tissue rejuvenation. These offer a large surface area to volume ratio to allow cell adhesion and exudate absorbing capacity and antibacterial properties. They also offer a better retention as well as sustained release of drugs that are directly impregnated to the scaffolds or the ones that are loaded in nanocarriers that are impregnated onto scaffolds. The present review comprehensively describes the pathogenesis of DW, various dressings that are used so far for DW, the limitation of currently used wound dressings, role of scaffolds in topical delivery of drugs, materials used for scaffold fabrication, and application of various polymer-based scaffolds for treating DW.

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Section: Materials Used In Scaffold Fabricationmentioning

confidence: 99%

Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds

Awasthi

Gulati

Kumar

et al. 2022

BioMed Research International

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“…Traditional techniques, such as freeze-thawing and chemical crosslinking, have been utilized to create hydrogels from poly (vinyl alcohol) (PVA)[ 17 ]. PVA scaffolds showed high mechanical properties and cytocompatibility, promoting regeneration of different tissues[ 18 - 21 ]. Under freeze-thaw cycles, Parameswaran-Thankam et al .…”

Section: Introductionmentioning

confidence: 99%

The Design and Characterization of a Strong Bio-Ink for Meniscus Regeneration

Lü¹,

Huang²,

Jin³

et al. 2022

IJB

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The meniscus is vital to the mechanical function of the knee, while it is frequently harmed because it bears a heavy load. A strong bio-ink for meniscus regeneration was prepared for the future meniscal tissue engineering. The prepared bio-ink consists of poly (vinyl alcohol) and decellularized extracellular matrix (PVA/dECM). The mechanical properties and the rheological features were explored to evaluate the effects of freezing/thawing cycles and alkaline treatment process. The printability was verified using a three-dimensional printer. The endothelial cells were employed to assess the biocompatibility. Finally, a 12-week rabbit meniscus defect model was established to evaluate the meniscus regeneration capability. We found that the bio-ink by soaking in alkaline for 40 min and 20 freezing/thawing cycles demonstrated excellent mechanical properties. The Young’s modulus reached 0.49 MPa and the stress limitation was 2.9 MPa. The results also showed good printability and biocompatibility of the proposed bio-ink in vitro. The PVA/dECM hydrogel healed the meniscus defect after 12 weeks of implantation. The articular cartilage and subchondral bone exhibited normal microstructure and composition. These results suggested that the PVA/dECM hydrogel could be a promising solution to repair meniscal lesions with preventive effects against degenerative meniscal tears and post-traumatic arthritis.

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Current application and modification strategy of marine polysaccharides in tissue regeneration: A review

Wang

Yang

et al. 2023

Biomaterials Advances

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A Marine-Derived Anti-Inflammatory Scaffold for Accelerating Skin Repair in Diabetic Mice

Cited by 7 publications

References 25 publications

Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds

Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds

The Design and Characterization of a Strong Bio-Ink for Meniscus Regeneration

Current application and modification strategy of marine polysaccharides in tissue regeneration: A review

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