A mass spectrometry-based approach gives new insight into organotin–protein interactions

Abstract

In this study, the combination of speciation analysis and native mass spectrometry is presented as a powerful tool to gain new insight into the diverse interactions of environmentally relevant organotin...

Trends and Advances in Inductively Coupled Plasma Tandem Quadruple Mass Spectrometry (ICP-QMS/QMS) With Reaction Cell

“…73 Furthermore, ICP-QMS/QMS has been covered by principle studies and reviews on the ICP-MS reaction/collision cell technology, 72,74,75 gas chromatography (GC-) ICP-MS, 76 and high performance liquid chromatography (HPLC-) ICP-MS for quantitative profiling analysis of metalloids in biological samples, 77 respectively. ion-gas molecule reaction, 73 isotope, 3,4,22-24,26-28,43-47,62-66,68, single particle, 5,6,15,31,40,[54][55][56][57] and chemical speciation, 7,8,[10][11][12]16,76,77 respectively.…”

“…Chemical speciation analysis. Chemical speciation analyses based on ICP-QMS/QMS were mostly reported for S, 7,10,11 Se, 7,10,11 Br, 8,12 Cl, 12 and Si 16 , all of which are "challenging elements" for traditional ICP-MS. Measurement at mass-shift mode using O2 as the cell gas was effective for separating spectral interferences in the analysis of S compounds and Se compounds in proteins, peptides and human blood cells.…”

“…Measurement at mass-shift mode using O2 as the cell gas was effective for separating spectral interferences in the analysis of S compounds and Se compounds in proteins, peptides and human blood cells. 7,10,11 Measurement at mass-shift mode using N2O as the cell gas and at on-mass mode using H2 was effective for separating the spectral interferences in the analysis of Br compounds in fish tissue and human plasma. 8,12 Measurement at mass-shift mode using H2 as the cell gas was effective for the analysis of Cl compounds (e.g.…”

Atomic Spectrometry Update: review of advances in elemental speciation

“…An MS based approach has been used by Will et al to study the interactions of environmentally relevant OTCs with proteins. 191 Analytical standards of model proteins, such as beta-lactoglobulin A (LGA), were incubated with different phenyl- and butyltins. For adduct identification and characterisation, the incubated samples were analysed by ICP-MS and ESI-MS coupled to SEC.…”