Background. Most patients adm itted to an intensive care unit (ICU) for mechanical ventilation require endotracheal intubation. Cuffed endotracheal tubes (ETTs) are utilised as they provide a better seal to facilitate ventilation and minimise aspiration. Complications due to overinflation or underinflation o f the cuff may occur. Neither the frequency o f in te rm itte nt cuff pressure (Pcuff) measurement nor the advantage o f continuous Pcuff m onitoring has been clearly established.Objective. To determ ine deviations in ETT Pcuff from the recommended range during the intervals between routine thrice-daily Pcuff measurements in adult ICU patients. Our key objective was to identify the extent and cause o f ETT Pcuff changes during these intervals. In addition, we attem pted to demonstrate the failure o f routine thrice-daily Pcuff m onitoring to detect the large variation in Pcuff o f patients throu gh ou t the day.Methods. This prospective, observational study was conducted in the King Edward VIII Hospital ICU, Durban, KwaZulu-Natal Province, South Africa. Ethical and institutional approval was obtained. Consent was obtained from patients' next o f kin. Interm ittent Pcuff was recorded using mechanical manometers, and continuous measurements using pressure transducers. Results. Thirty-five critically ill adult patients were enrolled. The mean study tim e was 11.1 h. The mean Pcuff was 25.6 (standard deviation 7.1) cmH20 for the interm ittent group and 26.6 (8.7) cmH20 for the continuous group.The interm ittent pressure measurements were in the low-pressure range (<20 cmH20) 12% of the tim e compared w ith 83% in the target pressure range (20 -30 cmH20) and 5% in the high-pressure range (>30 cmH20). For continuous pressures, 13% o f the tim e was spent in the low-pressure range, 64% in the target pressure range, and 23% in the high-pressure range. For the entire study, 588 events causing Pcuff alterations were recorded. Conclusion. Continuous m onitoring o f Pcuff indicated that the endotracheal Pcuff varied extensively during mechanical ventilation in critically ill patients, such variation being noted both between patients and w ithin individual patients. Variations in individual patients occurred both during intrinsic patient activities and those of ICU personnel as part of routine patient maintenance. Interm ittent m onitoring may not detect these variations. Continuous m onitoring of Pcuff during mechanical ventilation in ICUs is thus recommended for all patients.S