A mathematical model of the human menstrual cycle for the administration of GnRH analogues

Röblitz, Susanna; Stötzel, C.; Deuflhard, Peter; Jones, Hannah M.; Azulay, David-Olivier D; Graaf, Piet H. van der; Martin, Steven W.

doi:10.1016/j.jtbi.2012.11.020

Cited by 45 publications

(80 citation statements)

References 56 publications

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“…GnRH agonists act in a similar way of natural GnRH. They trigger an initial gonadotropins secretion which causes a subsequent testosterone production, but after such initial stimulation, they exert a long-term inhibitory effect via receptors 18,19 . It is reported that the use of buserelin significantly disrupts endocrine function and spermatogenesis in the testes.…”

Section: ■ Discussionmentioning

confidence: 99%

Short-term buserelin administration induces apoptosis and morphological changes in adult rat testes

et al. 2017

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Purpose: To investigate the effect of buserelin on gonadal structure and function in adult male rats. Methods: Twenty-four adult Wistar male rats were divided into three groups: two treated groups and controls. The first and second treated groups received 300 (low dose) and 500 (high dose) µg/kg buserelin, respectively, and the control group received normal saline. All groups were treated subcutaneously for five days. Results: The seminiferous tubular epithelial thickness was significant decreased in the treated groups compared with those in the control. There was a significant increase in apoptotic cell death in high dose treated group compared with low dose treated and control groups. No significant difference in serum testosterone level was observed after one month in the three groups. Conclusion: Buserelin induces apoptotic cell death and decreased diameter and epithelium thickness of seminiferous tubules in the adult rat testes.

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Section: ■ Discussionmentioning

confidence: 99%

Short-term buserelin administration induces apoptosis and morphological changes in adult rat testes

et al. 2017

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“…Russell, 1959 Fig. 1: Impressions of the seminar held in Berlin power and complexity of these models needed to form virtual patient cohorts (Röblitz et al, 2013). Liesbet Geris (University of Liège, KU Leuven, Belgium) showed translational applications of in silico methods when combined with different aspects of tissue engineering.…”

Section: Meeting Reportmentioning

confidence: 99%

In silico methods – Computational alternatives to animal testing

Lang

Volkamer

Behm

et al. 2018

ALTEX

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“…Research in Virtual Physiological Human (VPH) provides mechanistic quantitative models of the human physiology at levels of scale ranging from body compartments (see, e.g., [8,36]), organs (see, e.g., [7]) down to cells (see, e.g., [2]) or even molecules (see, e.g., [37]). …”

Section: Introductionmentioning

confidence: 99%

Computing Personalised Treatments through In Silico Clinical Trials. A Case Study on Downregulation in Assisted Reproduction.

Mancini

Mari

Massini

et al. 2018

EasyChair Preprints

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Abstract. In-Silico Clinical Trials (ISCT), i.e., clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce the need for animal and human testing, and enable precision medicine. In this paper we present a case study aiming at quantifying, by means of a multi-arm ISCT supervised by intelligent search, the potential impact of precision medicine approaches on a real pharmacological treatment, namely the downregulation phase of a complex clinical protocol for assisted reproduction.

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A mathematical model of the human menstrual cycle for the administration of GnRH analogues

Cited by 45 publications

References 56 publications

Short-term buserelin administration induces apoptosis and morphological changes in adult rat testes

Short-term buserelin administration induces apoptosis and morphological changes in adult rat testes

In silico methods – Computational alternatives to animal testing

Computing Personalised Treatments through In Silico Clinical Trials. A Case Study on Downregulation in Assisted Reproduction.

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