A matter of life and death: substance‐caused and substance‐related fatalities in Ibiza in 2015

Santacroce, Rita; Bennasar, Claudia Ruiz; Jaraiz, Juan Ramon Sancho; Fiori, F.; Sarchione, Fabiola; Angelini, Federica; Catalano, Gabriella; Carenti, Maria Luisa; Corkery, John; Schifano, Fabrizio; Giannantonio, Massimo Di; Martinotti, Giovanni

doi:10.1002/hup.2592

Cited by 12 publications

(10 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Within the still ongoing debate on the safety of recreational abuse of MDMA [61][62][63][64][65][66] our results, obtained using high doses of MDMA alone in a controlled experimental environment without concurrent different psychoactive substances, could help to provide evidence as to whether the use of amphetamine-like substances such as MDMA could acutely impair some functions (visual, acoustic, tactile responses, sensorimotor integration) that are fundamental in many facets of life (driving and workplace performance).…”

Section: Discussionmentioning

confidence: 81%

“…Furthermore, several studies suggest that MDMA has task specific effects on driving. According to recently published data, MDMA accounts for a remarkable number of fatalities, and it is detectable at a significant rate for traffic accidents [61]. However, as for many other drugs of abuse [16], a complex link between MDMA and driving is reported in the literature [62], suggesting that while MDMA could improve performance in some driving domains, other similarly relevant driving items could be negatively affected by MDMA [62].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

MDMA alone affects sensorimotor and prepulse inhibition responses in mice and rats: tips in the debate on potential MDMA unsafety in human activity

et al. 2018

View full text Add to dashboard Cite

Purpose MDMA is a psychoactive drug that has been increasingly abused worldwide, due to its entactogenic properties. However, concerns on its safety exist, particularly regarding its effects on attentional skills and performance. Evidence from the literature shows contrasting effects of MDMA. It generally acts as a pshychomotor stimulant, thus improving arousal and psychomotor function. However, MDMA has been demonstrated to negatively influence other skills. Consequently, human activities that require alertness, and accurate and quick reflexes (i.e. driving, operations at the workplace, etc.) could be negatively affected. In the present study, the effect of MDMA (0.1-20 mg/kg, intraperitoneally) on sensorimotor and startle/ prepulse inhibition responses was evaluated in a controlled rodent experimental setting. Methods Sensorimotor studies, evaluation of visual, acoustic, and tactile responses, evaluation of spontaneous locomotion, startle and repulse inhibition analyses were performed in an experimental controlled rodent model (rats and mice), following the administration of MDMA (0.1-20 mg/kg) intraperitoneally. Results Our findings show that all the MDMA-treated animals had impaired sensorimotor and prepulse inhibition responses compared to the control subjects at the early (5, 30 and 60 min) testing time points while all the effects disappeared, respectively, 6, 16 and 24 h post-MDMA treatment. Conclusions Within the ongoing debate on the safety of recreational abuse of MDMA, our results reveal acute prominent changes in sensorimotor and attentional performance, sensor response to external stimuli, and locomotor activity due to a single administration of a dose of MDMA (corresponding to a dose producing in humans both 'desirable' entactogenic effects and physiological adverse effects).

show abstract

Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

MDMA alone affects sensorimotor and prepulse inhibition responses in mice and rats: tips in the debate on potential MDMA unsafety in human activity

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The current dynamic drugs scenario raises enormous concerns for public health at a national and international level. The risks posed by club drugs and related phenomena require adequate training for health professionals, effective harm reduction interventions and updated policies provided by local and supranational regulatory agencies (30). Addressing these challenges may be crucial for guiding the diagnostic and therapeutic options of healthcare professionals, as well as for counteracting related psychiatric and physical risks, such as acute toxicity.…”

Section: Discussionmentioning

confidence: 99%

“…Our previous reports on this topic investigated substance-related fatalities and provided a first insight of traditional drug- and NPS-induced psychopathological symptoms, particularly regarding aggressiveness ( 30 , 33 ). The aim of the present study was to analyze patients admitted to the psychiatric ward of the Can Misses Hospital in Ibiza for psychoactive substance intoxication, in order to (a) report the sociodemographic characteristics of the sample, (b) identify which drug is most involved; (c) assess psychopathological features associated with substance use, particularly regarding psychotic symptoms (referring to bipolar or schizophrenic spectrum disorder) and behavioral disturbances.…”

Section: Introductionmentioning

confidence: 99%

Club Drugs: Psychotropic Effects and Psychopathological Characteristics of a Sample of Inpatients

et al. 2020

Self Cite

View full text Add to dashboard Cite

“…Furthermore, all (n=12) fatalities directly or indirectly related to misusing drugs registered in Ibiza from January to September 2015 were analysed. Most (9 out of 12) cases were males, with a mean age of 30.5 years, and two victims of 18 years-old were reported as well [51].…”

Section: Nps-related Fatalities In Youngstersmentioning

confidence: 99%

The use of new psychoactive substances (NPS) in young people and their role in mental health care: a systematic review

Orsolini

Chiappini

Corkery

et al. 2019

Expert Review of Neurotherapeutics

Self Cite

View full text Add to dashboard Cite

Introduction: Over the past ten years, a large number of New Psychoactive Substances (NPS) have entered the recreational drug scenario. NPS intake has been associated with health-related risks, and especially so for vulnerable populations such as the youngsters. Currently, most knowledge on the NPS health effects is learnt from both a range of users' reports, made available through the psychonauts' web fora, and from the few published, related toxicity, clinical observations. Areas covered: This paper aims at providing an overview of NPS effects on youngsters' mental health, performing a systematic review of the current related knowledge. Expert opinion: NPS consumption poses serious health risks, due to both a range of unpredictable clinical pharmacological properties and the typical concomitant use of other psychoactive molecules, which can lead to near misses and fatalities. In comparison with adults, the central nervous system of children/adolescents may be more vulnerable to the activity of these molecules, hence raising even further the levels of health-related concerns. Further research is needed, to provide evidence of both short-and long-term effects of NPS, related health risks, and their addiction potential.

show abstract

A matter of life and death: substance‐caused and substance‐related fatalities in Ibiza in 2015

Cited by 12 publications

References 19 publications

MDMA alone affects sensorimotor and prepulse inhibition responses in mice and rats: tips in the debate on potential MDMA unsafety in human activity

MDMA alone affects sensorimotor and prepulse inhibition responses in mice and rats: tips in the debate on potential MDMA unsafety in human activity

Club Drugs: Psychotropic Effects and Psychopathological Characteristics of a Sample of Inpatients

The use of new psychoactive substances (NPS) in young people and their role in mental health care: a systematic review

Contact Info

Product

Resources

About