A matter of taste

Persson, Pontus B.; Persson, Anja Bondke

doi:10.1111/apha.12023

Cited by 2 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study conforms with Good Publishing Practice in Physiology (Persson & Henriksson 2011). The protocols were approved by the Provincial State Office of Southern Finland (approval number STH059A).…”

Section: Experimental Animals Renal Ischaemia/reperfusion Caloric Rmentioning

confidence: 99%

Caloric restriction ameliorates kidney ischaemia/reperfusion injury through PGC‐1α–eNOS pathway and enhanced autophagy

et al. 2013

View full text Add to dashboard Cite

Aim: We investigated whether preconditioning with caloric restriction (CR) ameliorates kidney ischaemia/reperfusion (I/R) injury and whether the salutary effects of CR are mediated through enhanced autophagy and/ or activation of key metabolic sensors SIRT1, AMP-kinase and PGC-1a. Methods: Six-to seven-week-old Wistar rats were divided into three groups: (i) sham-operated group; (ii) I/R group (40-min ischaemia followed by 24 h of reperfusion); and (iii) I/R group kept under CR (energy intake 70%) for 2 weeks before surgery. In additional experiments, sirtinol and 3-methyladenine (3-MA) were used as inhibitors of SIRT1 and autophagy respectively. Renal function was measured, and acute tubular damage and nitrotyrosine expression were scored. Kidney adenosine monophosphateactivated kinase (AMPK), SIRT1, eNOS, PGC-1a and LC-3B expressions were measured. Results: Caloric restriction improved renal function, protected against the development of acute tubular necrosis and attenuated I/R-induced nitrosative stress. Kidney I/R injury decreased eNOS and PGC-1a expression, inhibit autophagy and increased SIRT1 and AMPK expressions by 2.6-and fourfold respectively. However, phosphorylation level of AMPK was decreased. As compared with I/R injury group, CR further increased kidney SIRT1 expression by 1.8-fold, promoted autophagy and counteracted I/R-induced decreases in the expression of eNOS and PGC-1a. 3-MA abolished the renoprotective effects of CR, whereas sirtinol did not influence renal function in CR rats with I/R injury. Conclusions: Caloric restriction ameliorates acute kidney I/R injury through enhanced autophagy and counteraction of I/R-induced decreases in the renal expression of eNOS and PGC-1a.

show abstract

Section: Experimental Animals Renal Ischaemia/reperfusion Caloric Rmentioning

confidence: 99%

Caloric restriction ameliorates kidney ischaemia/reperfusion injury through PGC‐1α–eNOS pathway and enhanced autophagy

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The material in this study is in conformity with Good Publishing Practice in Physiology (Persson & Henriksson 2011).…”

Section: Methodsmentioning

confidence: 75%

Prevention of duodenal ileus reveals functional differences in the duodenal response to luminal hypertonicity in Sprague‐Dawley and Dark Agouti rats

2013

View full text Add to dashboard Cite

The duodenum possesses the ability to absorb fluid despite a very high luminal osmolality. Inhibition of cyclooxygenase-2 markedly enhanced the capability of the duodenum to secrete fluid and to decrease luminal osmolality, irrespective of the hyperosmolar solution or the rat strain used, and revealed notable differences between the two strains with regard to their osmolality-adjusting capability.

show abstract

A matter of taste

Cited by 2 publications

References 23 publications

Caloric restriction ameliorates kidney ischaemia/reperfusion injury through PGC‐1α–eNOS pathway and enhanced autophagy

Caloric restriction ameliorates kidney ischaemia/reperfusion injury through PGC‐1α–eNOS pathway and enhanced autophagy

Prevention of duodenal ileus reveals functional differences in the duodenal response to luminal hypertonicity in Sprague‐Dawley and Dark Agouti rats

Contact Info

Product

Resources

About