An analysis of the dynamic response and damage assessment of partially confined metallic cylinders under transverse air-blast loading is presented in this paper. The examination of the blast shock wave load distribution and the consequences of standoff distances on the plastic deformation of cylinders was conducted with meticulous attention in the experimental testing. The charges of TNT were determined to have masses of 16.3[Formula: see text]kg and 29.5[Formula: see text]kg, while the distances at which they were placed from the target varied between 1.5[Formula: see text]m and 4.25[Formula: see text]m. Three unique deformation modes were found to exist in the unilaterally supported cylinder, all of which were directly connected to the distribution of the blast load. In order to obtain an improved understanding of the dynamic behaviors exhibited in cylinders, a finite element simulation model was utilized and subsequently validated using an examination of the experimental results. The assessment of shock wave damage was conducted by utilizing the residual deformation of the metallic cylinder as an equivalent characterization under lateral blast shock wave loading. The duration of the positive pressure zone of the shock wave was determined to be between one-fourth and ten times the vibration period of a unilaterally supported cylinder, indicating that the P-I (overpressure-impulse) criterion could be utilized for damage evaluation. The incorporation of the P-I criterion was subsequently employed to evaluate the detrimental consequences, taking into consideration the radial distribution of residual deformation identified in metal cylindrical shell constructions subjected to lateral blast shock wave loading. This research contributed to a better comprehension of the dynamic behavior of partially confined metallic cylinders subjected to lateral blast loading and highlights the significance of the P-I criterion for evaluating and mitigating the damage effects in such scenarios.