Measurement of the relative yields of ψ(2S) to ψ(1S) mesons produced at forward and backward rapidity in p+p, p+Al, p+Au, and The PHENIX Collaboration has measured the ratio of the yields of ψ(2S) to ψ(1S) mesons produced in p+p, p+Al, p+Au, and 3 He+Au collisions at √ s N N = 200 GeV over the forward and backward rapidity intervals 1.2 < |y| < 2.2. We find that the ratio in p+p collisions is consistent with measurements at other collision energies. In collisions with nuclei, we find that in the forward (p-going or 3 He-going) direction, the relative yield of ψ(2S) mesons to ψ(1S) mesons is consistent with the value measured in p+p collisions. However, in the backward (nucleus-going) direction, the ψ(2S) is preferentially suppressed by a factor of ∼2. This suppression is attributed in some models to breakup of the weakly-bound ψ(2S) through final state interactions with comoving particles, which have a higher density in the nucleus-going direction. These breakup effects may compete with color screening in a deconfined quark-gluon plasma to produce sequential suppression of excited quarkonia states.