A mechanistic view of the use of cold temperature in the treatment of cancer

The forgotten art of cold therapeutic properties in cancer: A comprehensive historical guide

“…Recently, in vivo 4°C cold exposure has been shown to induce brown adipose tissue activation, which competes and deprives cancer cells of glucose, thus inhibiting tumor growth in multiple cancer mouse models such as fibrosarcoma, breast cancer, colorectal cancer, melanoma, pancreatic ductal adenocarcinoma, and secondary liver cancer. 54 , 55 …”