A Mendelian randomization-based exploration of red blood cell distribution width and mean corpuscular volume with risk of hemorrhagic strokes

Liu, Jundong; Chou, Elizabeth L.; Lau, Kui Kai; Woo, Peter Yat Ming; Wan, Tsz Kin; Huang, Ruixuan; Chan, Kei Hang Katie

doi:10.1016/j.xhgg.2022.100135

Cited by 3 publications

(4 citation statements)

References 79 publications

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“…The higher dose of toxicity compound caused a risen of the level of MCH in liver disease such as cirrhosis by excessive alcohol drinking (J. Liu et al, 2022) and chronic liver disease (Rappai et al, 2019). The administration of PEE reduced the level of MCH as displayed in Table 2 due to Vitamin B12 in PEE to regulate the level of erythrocytes to maintain hemoglobin homeostatis in the rats exposured to DMBA.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective activity of ethanolic extract of Plectranthus amboinicus (lour.) spreng leaf in DMBA induced rats

Silitonga

Sinaga

Nugrahalia

et al. 2023

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Section: Discussionmentioning

confidence: 99%

Hepatoprotective activity of ethanolic extract of Plectranthus amboinicus (lour.) spreng leaf in DMBA induced rats

Silitonga

Sinaga

Nugrahalia

et al. 2023

Toxicon

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“…In accordance with the TOAST classification of stroke, IS participants were subdivided into three types in focus of infarction: large artery atherosclerotic ( n = 4,373 cases/40,611 controls), cardioembolic ( n = 7,193 cases/40,611 controls), and small vessel ( n = 5386 cases/192,662 controls) in this meta-analysis, represented by LAS, CES, and SVS, respectively ( 19 , 20 ). For hemorrhagic stroke, according to the FinnGen consortium ( 21 ), four hemorrhagic stroke outcomes were exhibited, including SAH (1,961 cases, and 281,638 controls), intracerebral hemorrhage (ICH, 2,643 cases and 281,373 controls), nontraumatic intracranial hemorrhage (nITH, 4,283 cases and 284,164 controls), and a combination of SAH, unruptured cerebral aneurysm, and aneurysm operations SAH (AOS) (3,201 cases and 284,164 controls) ( 21 ). Aneurysm operations in AOS are endovascular or surgical procedures to intracerebral aneurysms.…”

Section: Methodsmentioning

confidence: 99%

“…AOS was involved in hemorrhagic stroke outcomes due to the end-point attribute of SAH in AOS. According to how FinnGen defines the end point, nITH can be viewed as equivalent to hemorrhagic stroke based on the exclusion of other brain hemorrhages ( 21 ). As a result, we extracted summary statistics from the R7 release of the FinnGen consortium.…”

Section: Methodsmentioning

confidence: 99%

Twenty-three medication-taking traits and stroke: A comprehensive Mendelian randomization study

Shao

Wang

et al. 2023

Front. Cardiovasc. Med.

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BackgroundCertain medication categories may increase the risk of stroke. Nonetheless, the evidence regarding the causal relationship of medication-taking in promoting stroke and subtypes is deficient.MethodsWe evaluated the causal effect of a genetic predisposition for certain medication categories on stroke and subtypes (ischemic and hemorrhagic categories) by a two-sample Mendelian randomization (MR) analysis. Data for 23 medication categories were gathered from a genome-wide association study (GWAS) involving 318,177 patients. The Medical Research Council Integrative Epidemiology Unit Open GWAS database and the FinnGen consortium were used to gather GWAS data for stroke and subtypes. Inverse variance weighted, MR-Egger, and weighted median were used for the estimation of causal effects. Cochran's Q test, MR-Egger intercept test, and leave-one-out analysis were used for sensitivity analyses.ResultsTen medication categories were linked to a high stroke risk. Nine categories were linked to a high-risk ischemic stroke. Five categories were associated with small vessel ischemic stroke. Nine categories were positively associated with large artery atherosclerotic ischemic stroke. Three categories causally increased the possibility of cardioembolic ischemic stroke. Four categories were associated with intracerebral hemorrhage. Four categories were associated with nontraumatic intracranial hemorrhage. Three categories were causally associated with subarachnoid hemorrhage (SAH). Four categories were associated with the combination of SAH, unruptured cerebral aneurysm, and aneurysm operations SAH.ConclusionsThis study confirms that some medication categories lead to a greater risk of strokes. Meanwhile, it has an implication for stroke screening as well as direct clinical signiﬁcance in the design of conduction of future randomized controlled trials.

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“…In the past decades, large-scale genome-wide association studies (GWAS) have identified hundreds of genetic variants that are associated with cardiometabolic diseases ( 9 ) and with RDW ( 10 , 11 ). Based on that, Mendelian randomization (MR) studies are able to conduct examinations of the causal relationship between RDW, venous thromboembolism (VTE) ( 12 ) and haemorrhagic strokes ( 13 ). However, the application of MR analysis has often been limited to genome-wide significant variants, potentially leading to decreased statistical power due to the relatively small contribution of individual genetic variants in explaining the variance of complex traits ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Red cell distribution width and its polygenic score in relation to mortality and cardiometabolic outcomes

Pan,

Sun,

Goncalves

et al. 2023

Front. Cardiovasc. Med.

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IntroductionElevated red cell distribution width (RDW) has been associated with a range of health outcomes. This study aims to examine prognostic and etiological roles of RDW levels, both phenotypic and genetic predisposition, in predicting cardiovascular outcomes, diabetes, chronic kidney disease (CKD) and mortality.MethodsWe studied 27,141 middle-aged adults from the Malmö Diet and Cancer study (MDCS) with a mean follow up of 21 years. RDW was measured with a hematology analyzer on whole blood samples. Polygenic scores for RDW (PGS-RDW) were constructed for each participant using genetic data in MDCS and published summary statistics from genome-wide association study of RDW (n = 408,112). Cox proportional hazards regression was used to assess associations between RDW, PGS-RDW and cardiovascular outcomes, diabetes, CKD and mortality, respectively.ResultsPGS-RDW was significantly associated with RDW (Pearson's correlation coefficient = 0.133, p < 0.001). RDW was significantly associated with incidence of stroke (hazard ratio (HR) per 1 standard deviation = 1.06, 95% confidence interval (CI): 1.02–1.10, p = 0.003), atrial fibrillation (HR = 1.09, 95% CI: 1.06–1.12, p < 0.001), heart failure (HR = 1.13, 95% CI: 1.08–1.19, p < 0.001), venous thromboembolism (HR = 1.21, 95% CI: 1.15–1.28, p < 0.001), diabetes (HR = 0.87, 95% CI: 0.84–0.90, p < 0.001), CKD (HR = 1.08, 95% CI: 1.03–1.13, p = 0.004) and all-cause mortality (HR = 1.18, 95% CI: 1.16–1.20, p < 0.001). However, PGS-RDW was significantly associated with incidence of diabetes (HR = 0.96, 95% CI: 0.94–0.99, p = 0.01), but not with any other tested outcomes.DiscussionRDW is associated with mortality and incidence of cardiovascular diseases, but a significant association between genetically determined RDW and incident cardiovascular diseases were not observed. However, both RDW and PGS-RDW were inversely associated with incidence of diabetes, suggesting a putative causal relationship. The relationship with incidence of diabetes needs to be further studied.

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A Mendelian randomization-based exploration of red blood cell distribution width and mean corpuscular volume with risk of hemorrhagic strokes

Cited by 3 publications

References 79 publications

Hepatoprotective activity of ethanolic extract of Plectranthus amboinicus (lour.) spreng leaf in DMBA induced rats

Hepatoprotective activity of ethanolic extract of Plectranthus amboinicus (lour.) spreng leaf in DMBA induced rats

Twenty-three medication-taking traits and stroke: A comprehensive Mendelian randomization study

Red cell distribution width and its polygenic score in relation to mortality and cardiometabolic outcomes

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