A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease

Sexton, Claire E.; Kalu, Ukwuori G.; Filippini, Nicola; Mackay, Clare E.; Ebmeier, Klaus P.

doi:10.1016/j.neurobiolaging.2010.05.019

Cited by 313 publications

(292 citation statements)

References 73 publications

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“…There is still much debate about the pathophysiology of WML and several mechanisms have been proposed, including ischemia, blood-brain barrier alternations, apoptosis, chronic edema, genetic factors or a combination of the above (Pantoni, 2002). One theory proposed that WML occurs as a result of Wallerian degeneration, in which loss of axons runs parallel to the gray matter pathology and begins from the hippocampus and entorhinal region to the temporal and parietal association cortex (Sexton, Kalu, Filippini, Mackay, & Ebmeier, 2011). Conversely, another theory follows the retrogenesis model and proposes that white matter change is independent of the gray matter pathology.…”

Section: Discussionmentioning

confidence: 99%

Imaging and neuropsychological correlates of white matter lesions in different subtypes of Mild Cognitive Impairment: A systematic review

Lam

Yiend

Lee

2017

NRE

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Section: Discussionmentioning

confidence: 99%

Imaging and neuropsychological correlates of white matter lesions in different subtypes of Mild Cognitive Impairment: A systematic review

Lam

Yiend

Lee

2017

NRE

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“…A recent meta-analysis highlights the high variability in both the anatomy of regions studied and DTI metrics [201]. Also, a recent European multicenter study, the European DTI Study in Dementia (EDSD) [202], revealed significant center-related effect in DT-derived measures.…”

Section: Diffusion Tensor Imagingmentioning

confidence: 99%

Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: A long-range point of view beyond 2020

Hampel

Lista

Teipel

et al. 2014

Biochemical Pharmacology

105

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Recent advances in understanding the molecular mechanisms underlying various paths toward the pathogenesis of Alzheimer's disease (AD) has begun to provide new insight for interventions to modify disease progression. The evolving knowledge gained from multidisciplinary basic research has begun to identify new concepts for treatments and distinct classes of therapeutic targets; as well as putative disease-modifying compounds that are now being tested in clinical trials. There is a mounting consensus that such disease modifying compounds and/or interventions are more likely to be effectively administered as early as possible in the cascade of pathogenic processes preceding and underlying the clinical expression of AD. The budding sentiment is that "treatments" need to be applied before various molecular mechanisms converge into an irreversible pathway leading to morphological, metabolic and functional alterations that characterize the pathophysiology of AD. In light of this, biological indicators of pathophysiological mechanisms are desired to chart and detect AD throughout the asymptomatic early molecular stages into the prodromal and early dementia phase. A major conceptual development in the clinical AD research field was the recent proposal of new diagnostic criteria, which specifically incorporate the use of biomarkers as defining criteria for preclinical stages of AD. This paradigm shift in AD definition, conceptualization, operationalization, detection and diagnosis represents novel fundamental opportunities for the modification of interventional trial designs. This perspective summarizes not only present knowledge regarding biological markers but also unresolved questions on the status of surrogate indicators for detection of the disease in asymptomatic people and diagnosis of AD

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“…9 Fractional anisotropy (FA) is a quantitative index of diffusion derived from DTI and reflects the integrity of white matter microstructure. 10 Increased WMH burden, particularly in the periventricular and deep white matter, 3 and decreased microstructural white matter integrity measured using DTI 11 have led to a disconnection syndrome theory for the cognitive impairment seen in patients with MCI, MD and dementia. 12 Accordingly, a review of DTI studies in patients with MD showed a consistent reduction in FA of frontal and temporal white matter tracts compared with controls in region of interest (ROI) studies.…”

mentioning

confidence: 99%

Cognitive impairment with and without depression history: an analysis of white matter microstructure

Duffy

Paradise

Hickie

et al. 2014

J Psychiatry Neurosci

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A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease

Cited by 313 publications

References 73 publications

Imaging and neuropsychological correlates of white matter lesions in different subtypes of Mild Cognitive Impairment: A systematic review

Imaging and neuropsychological correlates of white matter lesions in different subtypes of Mild Cognitive Impairment: A systematic review

Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: A long-range point of view beyond 2020

Cognitive impairment with and without depression history: an analysis of white matter microstructure

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