A meta-analysis of DNA repair gene XPC polymorphisms and cancer risk

Abstract

Polymorphisms (A33512C, C21151T and PAT -/+) of the xeroderma pigmentosum group C (XPC) were shown to contribute to genetic susceptibility to cancer. However, association studies on these polymorphisms in cancer have shown conflicting results. Thus, we performed a meta-analysis. Overall, there was no significant association between 33512C (9,091 patients and 11,553 controls) and cancer risk. No significant association was found in stratification analysis by tumor sites and ethnicities except an elevated lung cancer risk under the recessive genetic model in all subjects [P = 0.04, odds ratio (OR) = 1.20, 95% confidence interval (CI) 1.00-1.45, P heterogeneity = 0.88]. There was no significant association between 21151T (5,227 patients and 5,959 controls) and cancer risk in all subjects but an increased cancer risk in Caucasians under the recessive genetic model (P = 0.006, OR = 1.45, 95% CI 1.11-1.90, P heterogeneity = 0.75) and homozygote comparison (P = 0.02, OR = 1.41, 95% CI 1.07-1.81, P heterogeneity = 0.41). It might be that 21151T increases bladder cancer risk under the recessive genetic model (P = 0.02, OR = 1.49, 95% CI 1.06-2.09, P heterogeneity = 0.47) and homozygote comparison (P = 0.02, OR = 1.49, 95% CI 1.05-2.11, P heterogeneity = 0.23). There was no significant association between PAT + (4,600 patients and 4,866 controls) and cancer risk in all subjects. An increased cancer risk in Caucasians was found under the recessive genetic model (P = 0.02, OR = 1.20, 95% CI 1.03-1.40, P heterogeneity = 0.37) and homozygote comparison (P = 0.008, OR = 1.26, 95% CI 1.06-1.50, P heterogeneity = 0.13). The XPC PAT + allele might increase head and neck cancer risk (P = 0.02, OR = 1.29, 95% CI 1.04-1.59, P heterogeneity = 0.15). More studies based on larger, stratified, case-control population, especially studies investigate the combined effect of XPC A33512C, C21151T, and PAT, are required to further evaluate the role of these polymorphisms in different cancers.

COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer

“…Only a minority of studies have reported case -control data on the same variants, allowing pooling of data (Table 1). Although P-values from meta-analyses of such studies provide limited support for the role of variants in MTHFR (Huang et al, 2007;Hubner and Houlston, 2007), CCND1 (Tan et al, 2008), GSTT1 (de Jong et al, 2002), XPC (Zhang et al, 2008), NQO1 (Chao et al, 2006) and NAT2 (Chen et al, 2005), such analyses should be interpreted with caution even if publication bias is ignored. Use of false-positive report probability value (FPRP) (Wacholder et al, 2004), which integrates the earlier probability for association and statistical power, provides one method for assessing the robustness of summary estimates derived from pooled analyses.…”

DNA Repair Capacity-Related to Genetic Polymorphisms of DNA Repair Genes and Aflatoxin B1-Related Hepatocellular Carcinoma Among Chinese Population

“…Thus, it may play a role in the pathogenesis www.intechopen.com of HCC-related AFB1. Some recent studies have showed that defects in XPC have been related to many types of malignant tumors (73)(74)(75)(76)(77)(78)(79)(80)(81)(82). Transgenic mice studies also revealed predisposition to many types of tumors in XPC gene knockout mice (83).…”

The Role of Molecular Mechanisms in the Development of Bladder Carcinoma: Review

“…Son za man lar da ya yın lan lan iki me ta ana liz de, nük le o tit ek siz yon ona rı mın da rol alan Xe ro der ma pig men to sum C (XPC) ge ni Ala499Val var yan tı nın me sa ne kan se ri ris ki ni ar tır dı ğı bil di ril miş tir. 138,139 Wu ve ark., 140 XPD Asp312 al le li nin, me sa ne kanse ri ris ki ni %28 ar tır dı ğı nı bil dir miş tir. Ga o ve ark.…”