A meta-analysis of scintimammography: an evidence-based approach to its clinical utility

Hussain, R; Buscombe, J. R.

doi:10.1097/00006231-200607000-00007

Cited by 23 publications

(8 citation statements)

References 23 publications

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“…Our results are in agreement with the meta-analyses of Waxman (52) and liberman et al (53). hussain and Buscombe in the meta-analysis study conclude that there is evidence that scintimammography is a robust imaging techinique delivering high sensitivities and specificities too (54).…”

Section: Discussionsupporting

confidence: 92%

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Accuracy of 99mTc-sestamibi scintimammography for breast cancer diagnosis

Moriguchi¹

2009

Exp Ther Med

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Abstract. Scintimammography using 99m tc-sestamibi is a noninvasive and painless diagnostic imaging method that is used to detect breast cancer when mammography is inconclusive. Because of the advantages of labeling with 99m Tc-sestamibi and its high efficiency in detecting carcinomas, it is the most widespread agent for this purpose. its accumulation in the tumor has multifactorial causes and does not depend on the presence of architectural distortion or local or diffuse density variation in the breast. the objective of this study was to evaluate the accuracy of scintimammography for detecting breast cancer. One hundred and fifty-seven patients presenting 158 palpable and non-palpable breast nodules were evaluated. three patients were male and 154 were female, aged between 14 and 81 years. all patients underwent scintimammography, and the nodule was subjected to cytological or histological study, i.e., the gold standard for diagnosing cancer. One hundred and eleven malignant and 47 benign nodules were detected, with predominance of ductal carcinomas (n=94) and fibroadenoma/fibrocystic condition (n=11/n=11), respectively. The mean size was 3.11 cm (7-10 cm) among the malignant nodules and 2.07 cm among the benign nodules (0.5-10 cm). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 89, 89, 95, 78 and 89%, respectively. analysis on the histological types showed that the technique was more effective on tumors that were more aggressive, such as ductal carcinoma. in this study, 99m tc-sestamibi scintimammography was shown to be an important tool for diagnosing breast cancer when mammography was inconclusive.Introduction mammography is the safest method for breast cancer screening (1-3). It presents good sensitivity for detecting palpable and non-palpable lesions and low specificity for distinguishing between benign and malignant processes (4). hence, a biopsy is often required for diagnostic confirmation (5). It also presents limitations in relation to detection of lesions in dense breasts (6-8). mann et al demonstrated that false negative mammograms cause delays in undertaking biopsies among patients with cancer (9). the high rates of unnecessary biopsies in cases of benign lesions (10) have encouraged research on non-invasive techniques with greater precision. ultrasound, magnetic resonance imaging, positron emission tomography and scintigraphy are important aids for detecting cancer when mammography is indeterminate (11). high-risk patients (e.g., family antecedents, atypical proliferative lesions and previous cancer subjected to tumorectomy or radiotherapy) have benefited from combined use of these methods (11). Scintigraphy is a noninvasive imaging examination that uses small doses of radiation (12). it is painless, its cost and availability are reasonable and it enables functional or metabolic evaluation of various organs or structures. its advantage is unequivocal, especially when analysis using other methods is limited, and it stands out as a diagnostic eva...

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Section: Discussionsupporting

confidence: 92%

“…Such tumors present high expression of cellular proliferation factors, high mitotic rates, intense angiogenesis and high mitochondrial activity and density. these factors are the main determinants for the concentration of 99m tc-sestamibi in the lesion (13)(14)(15)(16)(17)54,55).…”

Section: Benign Nodules Scintimammography ---------------------------mentioning

confidence: 99%

Accuracy of 99mTc-sestamibi scintimammography for breast cancer diagnosis

Moriguchi¹

2009

Exp Ther Med

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“…Therefore, as suggested by Prats et al [6], the adoption of SM in the diagnostic protocol can considerably reduce the number of biopsies performed in patients with lesions of low or indeterminate mammographic suspicion of malignancy with a diameter >1 cm (sensitivity: 94%; specificity: 75%, positive predictive value-PPV: 73% and negative predictive value-NPV: 95%). A recent meta-analysis for establishing the evidence based for the clinical use of SM, performing on 2,424 patients showed an overall sensitivity of 85% and specificity of 84% [7].…”

Section: Conventional Nuclear Imaging Breast Scintigraphymentioning

confidence: 99%

Nuclear Imaging and Early Breast Cancer Detection

Evangelista¹,

Burei²,

Cervino³

2012

J Cancer Sci Ther

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“…Afterwards, in June 1997, 99m Tc-sestamibi has been the first radiopharmaceutical, which was approved by the Food and Drug Administration in the USA for radionuclide breast imaging [11]. Nowadays, 99m Tc-sestamibi is licensed for identification of breast cancer in most European countries as well [12,13]. It was the group by Khalkhali, which consecutively devised and popularized the technique of 99m Tcsestamibi scintimammography [10,14].…”

Section: Introductionmentioning

confidence: 99%

99mTc-Sestamibi Scintimammography

Bucerius

2011

99mTc-Sestamibi

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From an anatomical point of view, the mammary gland is part of the female secondary sexual characteristics. The primary biological function of the mammary glands is the feeding of infants with breast milk. The mammary glands belong to the major glands of the cutis (glandulae cutis) and develop from epithelial cones, which grow in the surrounding connective tissue. Initially, the mammary glands are established in the same way in both genders.The female mammary glands are located on the major and minor pectoral muscles (M. pectoralis major, M. pectoralis minor) between the third and the seventh rib and between the sternal-and axillary line. The arterial blood supply of the mammary glands is provided by vascular branches (R. mammarii mediales and laterales) of the internal and lateral thoracic arteries (A. thoracica interna, A. thoracica lateralis) as well as by branches (R. preforantes and R. mammarii laterales) of the anterior and posterior intercostal arteries (Aa. intercostales anterior and posterior). The venous drain follows from superficial veins into the lateral and internal thoracic veins (Vv. thoracica lateralis and interna). The mammary glands are characterized by numerous lymphatic vessels, which build a superficial and deep lymphatic mesh with several directions of lymphatic drainage. From a clinical point of view, the main and most important lymphatic drainage reaches the axillary lymph nodes. Additional lymphatic drains flow off to the cervical lymph nodes superior to the clavicles and via the interpectoral lymphatic nodes (N. lymphatici interpectorales) between the pectoral muscles to the axillary lymph nodes, via the parasternal lymph nodes (N. lymphatici parasternales) along the internal thorac vein, and via the

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A meta-analysis of scintimammography: an evidence-based approach to its clinical utility

Abstract: There is evidence that this is a robust imaging technique delivering high sensitivities and specificities in patients studied in both single-centre and multi-centre trials and, as such, can be relied on as an adjunctive method for the investigation of primary breast cancer.

Cited by 23 publications

References 23 publications

Accuracy of 99mTc-sestamibi scintimammography for breast cancer diagnosis

Accuracy of 99mTc-sestamibi scintimammography for breast cancer diagnosis

Nuclear Imaging and Early Breast Cancer Detection

99mTc-Sestamibi Scintimammography

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