A meta-analysis of sensitization to the most common aeroallergens in a Middle Eastern region: an overview of the main molecular allergens

Shoormasti, Raheleh Shokouhi; Sabetkish, Nastaran; Kazemnejad, Anoshirvan; Vahabi, Nasim; Fazlollahi, Mohammad Reza; Pourpak, Zahra; Mari, Adriano; Moin, Mostafa

doi:10.1007/s10453-019-09586-y

Cited by 6 publications

(3 citation statements)

References 138 publications

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“…The occurrence of AR in asthmatic patients has been addressed in previous large-scale studies and in the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines (31)(32)(33). Our AR prevalence in asthmatic patients (79%) is higher than studies in Saudi Arabia (33%) (34), Iran (47%) (35), Japan (67%) (36), Italy (60%) (37), and France (66%) (38) but is lower than the United States (94%) (39). There was concordance between the ISAAC-definition of AR and clinical diagnoses, indicating that diagnosis by clinicians was as reliable as the standard questionnaire used in epidemiological surveys.…”

Section: Discussionmentioning

confidence: 93%

Allergic rhinitis and other comorbidities associated with asthma control in Thailand

Sriprasart,

Saiphoklang,

Kawamatawong

et al. 2024

Front. Med.

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BackgroundAsthma and allergic rhinitis (AR) can coexist and cause disabilities. This study aimed to assess the association between AR, asthma control, asthma-related quality of life, and other comorbidities.MethodsA cross-sectional study was conducted in adults with asthma in six hospitals in Thailand. The outcomes were association of asthma control assessed by the asthma control test (ACT), AR, and asthma comorbidities. Not-well-controlled asthma was defined as ACT scores ≤22. The severity of AR was determined by visual analog scale (VAS). Severe AR was defined as VAS ≥5. Asthma-related quality of life (AQLQ), comorbidities, and total IgE were recorded.ResultsA total of 682 asthmatic patients were included. Median (IQR) age was 58.0 (47.0–64.0) years. 69.9% were female. Not-well-controlled asthma was present in 44.7%. The prevalence of AR was 86.1%. Moderate/severe persistent AR was diagnosed in 21.7% and severe AR was diagnosed in 30.2% of the patients. Inhaled corticosteroid-containing regimens were prescribed in 97.7% of patients. Intranasal corticosteroid and antihistamine were prescribed in 65.7 and 31.7%, respectively. Patients with not-well-controlled asthma had higher body mass index, VAS scores, proportions of pollution exposure, aeroallergen sensitization, severe AR, nasal polyp, urticaria, food allergy, gastroesophageal reflux disease, depression and anxiety, peptic ulcer, and asthma exacerbations, but younger age, lower AQLQ scores, and lower FEV1. Correlation was found between AR severity and ACT (r = −0.461, p < 0.001), AQLQ (r = −0.512, p < 0.001), and total IgE (r = 0.246, p < 0.023). Multiple regression analysis revealed that ACT, AQLQ, and percentage of FEV1/FVC were significantly associated with severe AR.ConclusionAllergic rhinitis is prevalent in Thai asthmatic patients. AR severity is associated with asthma control, quality of life, and pulmonary function. Comprehensive care is essential for patients with uncontrolled asthma, particularly when coexisting with conditions.

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Section: Discussionmentioning

confidence: 93%

Allergic rhinitis and other comorbidities associated with asthma control in Thailand

Sriprasart,

Saiphoklang,

Kawamatawong

et al. 2024

Front. Med.

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“…House dust mites (HDM) are considered as one of the most important indoor aeroallergens developing allergic diseases 37 which with about 39 and 38 allergenic molecules has been being recognized for Dermatophagoides farina and Dermatophagoides pteronyssinus respectively (http://www.allergome.org). According to a meta‐analysis by Shokouhi et al, a 38% prevalence of HDM sensitization has been reported in Iran 38 . Among house dust mite allergens in the FABER profile, Der p 2 and Der f 2 which belong to the NPC2 protein family 39 were the most prevalent.…”

Section: Discussionmentioning

confidence: 99%

Molecular profile of specific IgE to allergenic components in allergic adults using allergen nano‐bead array

Shoormasti

Rafaiani²,

Fazlollahi

et al. 2022

Clin Experimental Allergy

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Background An increasing interest in the field of molecular diagnosis of allergy has been developed in recent years and it goes to be as the routine in vitro protocol in allergy diagnosis. friendly allergen nano‐bead array (FABER) is a new multiplex assay for the evaluation of specific IgE against 244 allergens including whole extracts and allergenic molecules. The research intended to assess the pattern of IgE sensitization to allergenic components of allergens in allergic adults using FABER 244. Methods Sixty patients with allergic diseases entered this cross‐sectional study. Specific IgE to 122 whole allergens extracts and 122 allergenic components were assessed using an allergen nano‐bead array (FABER) for all patients. This test includes inhalant and food allergens. Results Thirty‐seven patients were male (61.7%). The mean (SD) age of patients was 30.73(±6.87) years. As the allergen nano‐bead array results showed, Lolium perenne (63.3%), Phleum pratense (60%) and Platanus acerifolia (51.7%) were considered as the most common IgE sensitizations to the aeroallergen extracts. Moreover, Lol p 1, Phl p 1.0102 and Cup a 1 were found as the most frequent allergenic components in our allergic patients. Among protein families, CCD‐bearing proteins, expansin, cysteine protease and profilin families illustrated the highest allergic sensitization. Conclusions The results of the present study demonstrated that despite the higher prevalence of sensitization to Salsola kali (47.2%) using extract‐based assays in the previous phase of this research, allergenic components of grasses (Lol p 1, Phl p 1.0102), Cup a 1 as well as Sal k1 as the major components of Cupressuss arizonica and Salsola kali showed the higher sensitization, respectively, in adults’ allergic patients using FABER test.

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“…They are common allergic diseases and the incidence is increasing year by year. The worldwide prevalence of AR, AC, and ARC has been reported to be 28.3%, 15.9%, and 12.3%, respectively (3).…”

Section: Introductionmentioning

confidence: 99%

Characterization of dysbiosis of the conjunctival microbiome and nasal microbiome associated with allergic rhinoconjunctivitis and allergic rhinitis

Wang

et al. 2023

Front. Immunol.

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BackgroundAllergic rhinoconjunctivitis (ARC) and allergic rhinitis (AR) are prevalent allergic diseases. People are becoming increasingly aware of the impact of microbial disorders on host immunity and allergic diseases. Studies have demonstrated an association between allergic diseases and the microbiome, but much remains unknown. We assessed changes in the conjunctival microbiome and nasal microbiome in patients with ARC or AR.MethodsConjunctival swabs and nasal swabs were collected from each participant for 16S rRNA amplicon sequencing. Bacterial communities were analyzed.ResultsForty patients with ARC, 20 patients suffering from AR, and 34 healthy controls (HCs) were recruited. This study found the abundance of conjunctival microbiome in patients with ARC or AR was significantly lower than that in HCs. The diversity of conjunctival microbiome in patients with AR was significantly lower than those in the other two groups. There is no significant difference in abundance of nasal microbiome between the three groups. The diversities of nasal microbiome in patients with ARC or AR were significantly lower than that in HCs. We found significant differences in microbiota compositions in patients with ARC or AR compared with those in HCs. However, no significant difference in microbiota compositions was found between patients with ARC and patients with AR. Microbiome functions in the ARC group and AR group were also altered compared with HCs.ConclusionsWe revealed changes in the composition and function of the conjunctival microbiome and nasal microbiome of patients with ARC or AR, which suggests that there is a relationship between allergic conditions and the local microbiome.

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A meta-analysis of sensitization to the most common aeroallergens in a Middle Eastern region: an overview of the main molecular allergens

Cited by 6 publications

References 138 publications

Allergic rhinitis and other comorbidities associated with asthma control in Thailand

Allergic rhinitis and other comorbidities associated with asthma control in Thailand

Molecular profile of specific IgE to allergenic components in allergic adults using allergen nano‐bead array

Characterization of dysbiosis of the conjunctival microbiome and nasal microbiome associated with allergic rhinoconjunctivitis and allergic rhinitis

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