A meta-analysis of the association of serum ischaemia-modified albumin levels with human hypothyroidism and hyperthyroidism

Abstract

Serum levels of ischaemia-modified albumin (IMA) have been studied as a novel and simple measure of oxidative stress (OXS) in different thyroid pathologies. However, results of available studies in the literature were not consistent. This meta-analysis was attempted to quantify the overall effect size for serum IMA levels in human hypothyroidism (HT) and hyperthyroidism (HYT) and to study its associations with the thyroid profile. Databases of PubMed/Medline, EMBASE, Google Scholar, Web of Science and Science Direct were searched for articles. Data on serum IMA levels in HT, HYT patients and euthyroid controls were extracted to compute standardized mean differences (SMD) by the random-effects model. The associations between IMA and thyroid profile were computed by the meta-analysis of correlation coefficients. IMA levels in HT patients (SMD=1.12; Z=2.76; P=0.006) and HYT patients (SMD=1.64; Z=2.57; P=0.01) were significantly higher than in euthyroid controls and the thyroid treatment showed a favourble effect on serum IMA levels. There were strong and significant correlations between IMA and hormonal status in HT and HYT groups. This meta-analysis showing increased IMA level in both HT and HYT patients and its association with thyroid profile suggests that serum IMA could be used as a simple measure of increased OXS in thyroid dysfunction.

Ischemia-Modified Albumin: Origins and Clinical Implications

“…IMA has been proposed as an early biomarker for various diseases associated with ischemia and oxidative stress, including myocardial infarction and cerebrovascular accidents, diabetes mellitus and renal failure, and hypothyroidism and hyperthyroidism [21,23,42,66]. Mounting experimental data suggest that this marker is ambiguous and that its values depend on the type and stage of the pathological process and methods used.…”

Evaluation of Oxidative Stress with a New Method in Differentiated Thyroid Cancer Patients on Thyrotrophin Suppression Treatment

“…Thyroid hormones play a role in regulating mitochondrial respiration and oxidative metabolism, affecting free radical production and OS. Accelerated basal metabolic rate and oxidative metabolism in hyperthyroidism lead to an increased free radical generation and OS (9). The literature re-fT3: Free triiodothyronine; fT4: Free thyroxine.…”

“…Thyroid hormones have an essential role in regulating mitochondrial respiration and oxidative metabolism, which further affects oxidative stress (OS). Therefore, OS levels might be affected by variations in thyroid hormones (9). Previous studies have shown that high serum fT3 and fT4 stimulate free radicals in mitochondria and cause an increase in OS (10,11).…”

Investigation of the effect of vitamin C on the oxidative stress parameters induced by i-131 treatment applied in patients with hyperthyroidism

“…While, as reported in many studies, IMA which is an indicator of ischemia and oxidative stress may increase especially in cardiac ischemia, it is understood from the literature that it may also increase in many noncardiac diseases [41,42]. Reddy VS et al identified the relationship between IMA and thyroid diseases in a meta-analysis and they reported that IMA values increase in both hypothyroidism and hyperthyroidism and can be easily measured as an oxidative stress parameter in thyroid dysfunctions [43]. In our study results, it was seen that Vit C support was not able to prevent IMA formation.…”