A metabolomic study of preterm and term human and formula milk by proton MRS analysis: preliminary results

Longini, Mariangela; Tataranno, Maria Luisa; Proietti, Fabrizio; Tortoriello, Mario; Belvisi, Elisa; Vivi, Antonio; Tassini, Maria; Perrone, Serafina; Buonocore, Giuseppe

doi:10.3109/14767058.2014.955958

Cited by 31 publications

(34 citation statements)

References 21 publications

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“…Compared with colostrum and mature milk of mothers of preterm infants, transitional milk has lower ORP value indicating better TAC than colostrum or mature milk. Breast milk from mothers of preterm infants of 29–34 gestation weeks, collected up to 40 weeks of postnatal age showed a temporal change over the first 3 weeks of lactation, approaching zero with the achievement of term age . Our results indicate that TAC of transitional milk (according to ORAC value, up to 70% of TAC is in whey) is mainly due to the presence of vitamin C. Clausen et al .…”

Section: Discussionsupporting

confidence: 51%

“…Breast milk from mothers of preterm infants of 29-34 gestation weeks, collected up to 40 weeks of postnatal age showed a temporal change over the first 3 weeks of lactation, approaching zero with the achievement of term age. 26 Our results indicate that TAC of transitional milk (according to ORAC value, up to 70% of TAC is in whey) is mainly due to the presence of vitamin C. Clausen et al concluded that the number of significant contributors to milk radical scavenging activity is relatively low. 27 The TAC of milk does not correspond to the presence of peroxidation products in human milk, 28 also indicating that ORAC value may not be fully adequate as the representative of TAC in milk.…”

Section: Discussionmentioning

confidence: 54%

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Redox properties of transitional milk from mothers of preterm infants

Minić

Jesic

Đurović

et al. 2017

J Paediatrics Child Health

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 54%

Redox properties of transitional milk from mothers of preterm infants

Minić

Jesic

Đurović

et al. 2017

J Paediatrics Child Health

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“…Metabolomic studies have been performed both on HM [ 5 , 37 , 93 , 94 , 95 , 96 , 97 , 98 ] and BM [ 35 , 99 , 100 , 101 , 102 ] that have also focused on metabolite changes during lactation [ 37 ]. HM metabolome, evaluated with nuclear magnetic resonance spectroscopy (NMR), has shown differences according to Gestational Age (GA), lactation phase [ 35 ], exposure to exogenous substances and it is different from BM and formula milk (FM).…”

Section: Metabolomicsmentioning

confidence: 99%

“Omics” in Human Colostrum and Mature Milk: Looking to Old Data with New Eyes

2017

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Human Milk (HM) is the best source for newborn nutrition until at least six months; it exerts anti-inflammatory and anti-infective functions, promotes immune system formation and supports organ development. Breastfeeding could also protect from obesity, diabetes and cardiovascular disease. Furthermore, human colostrum (HC) presents a peculiar role in newborn support as a protective effect against allergic and chronic diseases, in addition to long-term metabolic benefits. In this review, we discuss the recent literature regarding “omics” technologies and growth factors (GF) in HC and the effects of pasteurization on its composition. Our aim was to provide new evidence in terms of transcriptomics, proteomics, metabolomics, and microbiomics, also in relation to maternal metabolic diseases and/or fetal anomalies and to underline the functions of GF. Since HC results are so precious, particularly for the vulnerable pre-terms category, we also discuss the importance of HM pasteurization to ensure donated HC even to neonates whose mothers are unable to provide. To the best of our knowledge, this is the first review analyzing in detail the molecular pattern, microbiota, bioactive factors, and dynamic profile of HC, finding clinical correlations of such mediators with their possible in vivo effects and with the consequent impact on neonatal outcomes.

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“…Compared to the metabolites in preterm formula milk, the aqueous extracts of preterm HM were shown to have high lactose concentrations. The preterm formula milk, on the other hand, had a higher concentration of maltose [21,22]. The HM metabolome was further explored by Practico et al [23] with NMR spectroscopy.…”

Section: Human Milk Metabolomementioning

confidence: 99%

The Determinants of the Human Milk Metabolome and Its Role in Infant Health

et al. 2020

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Human milk is needed for optimal growth as it satisfies both the nutritional and biological needs of an infant. The established relationship between breastfeeding and an infant’s health is attributable to the nutritional and non-nutritional, functional components of human milk including metabolites such as the lipids, amino acids, biogenic amines and carbohydrates. These components have diverse roles, including protecting the infant against infections and guiding the development of the infant’s immature immune system. In this review, we provide an in-depth and updated insight into the immune modulatory and anti-infective role of human milk metabolites and their effects on infant health and development. We also review the literature on potential determinants of the human milk metabolome, including maternal infectious diseases such as human immunodeficiency virus and mastitis.

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A metabolomic study of preterm and term human and formula milk by proton MRS analysis: preliminary results

Abstract: Metabolome is a promising tool to study human and artificial milk global metabolic profile.

Cited by 31 publications

References 21 publications

Redox properties of transitional milk from mothers of preterm infants

Redox properties of transitional milk from mothers of preterm infants

“Omics” in Human Colostrum and Mature Milk: Looking to Old Data with New Eyes

The Determinants of the Human Milk Metabolome and Its Role in Infant Health

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