2022
DOI: 10.3390/ma15175802
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A Metal-Containing NP Approach to Treat Methicillin-Resistant Staphylococcus aureus (MRSA): Prospects and Challenges

Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of pneumonia in humans, and it is associated with high morbidity and mortality rates, especially in immunocompromised patients. Its high rate of multidrug resistance led to an exploration of novel antimicrobials. Metal nanoparticles have shown potent antibacterial activity, thus instigating their application in MRSA. This review summarizes current insights of Metal-Containing NPs in treating MRSA. This review also provides an in-depth app… Show more

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Cited by 6 publications
(4 citation statements)
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“…Their ability to produce ROS and interact with the MRSA cell membrane and structures are the key mechanisms of their antibacterial effects. However, metallic NPs are not selective for bacterial cells, causing toxicity towards healthy animal/human cells, which restricts their clinical applications [70]. The use of targeting strategies is therefore mandatory to overcome this limitation.…”
Section: Discussion and Concluding Remarksmentioning
confidence: 99%
“…Their ability to produce ROS and interact with the MRSA cell membrane and structures are the key mechanisms of their antibacterial effects. However, metallic NPs are not selective for bacterial cells, causing toxicity towards healthy animal/human cells, which restricts their clinical applications [70]. The use of targeting strategies is therefore mandatory to overcome this limitation.…”
Section: Discussion and Concluding Remarksmentioning
confidence: 99%
“…They find wide applications in biomedicine, including wound healing, cell imagining, diagnostics, and contraceptive devices. In the context of biofilm infections, AgNPs exhibit enhanced antibacterial activity, as demonstrated in in vitro studies [142]. Synergistic effects against MRSA were observed when amoxicillin was combined with gold nanoparticles (AuNPs) [143].…”
Section: Innovative Therapeutic Strategies Against S Aureus and Resis...mentioning
confidence: 99%
“…Metals have the ability to form various chemical bonds with polymers, and metals can also have intrinsic pharmacological activity (e.g., antitumor, antibacterial, wound healing, etc.). Incorporation of metals into the polymer matrix can improve its mechanical properties, retard erosion, and enhance biological effects [113,238,239]. For example, Mahmoud et al [240] developed mucoadhesive hydrogel composites based on acrylic acid, polyethylene glycol and zinc oxide nanoparticles for local buccal delivery of propranolol.…”
Section: Nanotechnology-based Systems To Improve Buccal Drug Deliverymentioning
confidence: 99%