A Metal‐Ion‐Incorporated Mussel‐Inspired Poly(Vinyl Alcohol)‐Based Polymer Coating Offers Improved Antibacterial Activity and Cellular Mechanoresponse Manipulation

Abstract

Cobalt (CoII) ions have been an attractive candidate for the biomedical modification of orthopedic implants for decades. However, limited research has been performed into how immobilized CoII ions affect the physical properties of implant devices and how these changes regulate cellular behavior. In this study we modified biocompatible poly(vinyl alcohol) with terpyridine and catechol groups (PVA‐TP‐CA) to create a stable surface coating in which bioactive metal ions could be anchored, endowing the coating with improved broad‐spectrum antibacterial activity against Escherichia coli and Staphylococcus aureus, as well as enhanced surface stiffness and cellular mechanoresponse manipulation. Strengthened by the addition of these metal ions, the coating elicited enhanced mechanosensing from adjacent cells, facilitating cell adhesion, spreading, proliferation, and osteogenic differentiation on the surface coating. This dual‐functional PVA‐TP‐CA/Co surface coating offers a promising approach for improving clinical implantation outcomes.

Antibacterial black phosphorus nanosheets for biomedical applications

“…36,37 However, the research and development process of new antibiotics is extremely expensive (up to $1581 million) and usually takes more than a decade to complete, which lags far behind the time of antibioticresistance development. 29,38,39 To address the urgent need for effectively treating drug-resistant bacterial infections, researchers have turned to non-antibiotic antibacterial materials such as antibacterial peptides, [40][41][42] metal ions, 43,44 carbon-based nanomaterials, 45,46 and quaternary ammonium salt. 47 Among these materials, antimicrobial peptides are particularly promising due to their highly selective antimicrobial activity and low likelihood of developing bacterial resistance.…”

Functionally Tailored Metal–Organic Framework Coatings for Mediating Ti Implant Osseointegration

“…Interestingly, the metal species in MOF structures could offer intrinsic biochemical reactivity that are not commonly found in organic materials, which provide unprecedented opportunities for introducing novel pro‐osseointegration functionalities into Ti implants. [ 60 ] From an overall perspective, the primary therapeutic function of metal components in MOF coatings include (1) stimulating osteogenic functions of osteogenesis‐related cells and (2) inhibiting local biofilm formation and infection after implantation.…”

Terahertz Spectroscopic Insight into the Hydrogelation of Copper Ion-Coordinated Poly(vinyl alcohol)

“…For example, Wang et al used PVA as the main raw material in combination with acrylic acid (AA) and metal ions to prepare a tri-crosslinked network of antimicrobial hydrogels with good mechanical properties [9]. Gao et al prepared PVA/PAA/Fe 3+ -GaIn hydrogel with certain antimicrobial properties and a good mechanical response [10]. In these works, various methods, including FTIR, UV-vis spectra [11][12][13][14] and EDS, XRD, XPS [15][16][17][18][19] and NMR [20], were used to study the interaction between metal ions and polymers.…”