A metastable β-type Zr-4Mo-4Sn alloy with low cost, low Young's modulus and low magnetic susceptibility for biomedical applications

Guo, Shun; Shang, Yao; Zhang, Jinming; Zhang, Junsong; Meng, Qingkun; Cheng, Xiaonong; Zhao, Xiaohu

doi:10.1016/j.jallcom.2018.04.279

Cited by 22 publications

(4 citation statements)

References 31 publications

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“…Figure 3 also shows that while the Zr-based materials have the lowest magnetic susceptibilities, the Ti-based materials are the second lowest magnetic susceptibilities. Nonetheless, Ti-6Al-4V and cp Ti-Gr2 still exhibit values almost three or two times larger than the Zr-based materials, consistent with previous investigations 7,10,11,17,28,30 . Based on these promising results, it is usually claimed that the reduced magnetic susceptibilities of Zr-based materials could sharply reduce the occurrence of MRI artifacts.…”

Section: Resultssupporting

confidence: 91%

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Appraising the potential of Zr-based biomedical alloys to reduce magnetic resonance imaging artifacts

Suzuki

Campo

Fonseca

et al. 2020

Sci Rep

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this study compared Zr-Mo alloys with commercial metallic biomaterials. it was observed that the Zr-Mo alloys exhibited favourable mechanical properties, particularly the Zr-10Mo alloy, which showed the highest strength to Young's modulus ratio among all evaluated metals. these alloys also exhibited the lowest magnetic susceptibilities, which are important for magnetic resonance imaging (MRi). However, both Zr-and ti-based metals yielded comparable artifacts. it was concluded that the magnetic susceptibility must differ considerably to afford significantly improved MRI quality owing to the increased importance of non-susceptibility-related artifacts when comparing materials with relatively similar magnetic susceptibilities. Metals are still competitive with other classes of materials in the application and development of medical implants in various fields of medicine, such as orthopaedics, neurology, cardiology, and dentistry. Owing to their combined properties, including strength and toughness, and the possibility of employing cost-effective manufacturing processes, metals are typically the best biomaterial choice when compared to ceramics and polymers, as well as composites. The use of metallic devices in the human body is usually required for the replacement and stabilization of damaged bone tissues in orthopaedic practice. The classical examples of such applications include temporary plates and screws, and permanent total hip replacements. Other applications include usage in vascular stents, aneurysm clips, pacemakers, dental implants, wire sutures, etc. 1-3. Despite being similar to Ti alloys, particularly in their physical metallurgy and other properties 4 , Zr-based alloys have received comparatively little attention as biomaterials. Zr and its alloys exhibit excellent biocompatibility, good corrosion behaviour, and favourable mechanical properties 5-11. Specifically, these alloys are suitable for applications in orthopaedic and dentistry owing to their low Young's modulus. A major issue associated with using metallic materials in long-term implants is the mismatch between the bone and the employed device. Rigid implants can promote the stress shielding effect and cause bone resorption, strongly affecting the medium-to long-term quality of the surgical intervention 12. Accordingly, alloys with a low Young's modulus have been targeted for this type of application 13,14. In this regard, Zr alloys are similar to Ti alloys. For instance, Guo et al. 10 reported a Young's modulus of only 44 GPa for a β-type Zr-12Nb-4Sn alloy, which is relatively close to that of human cortical bone (around 20 GPa 15) and is similar to as the best results reported for Ti alloys 16. More recently, increasing interest in Zr and its alloys has been justified by their reduced magnetic susceptibility, which has been claimed to reduce the magnetic resonance imaging (MRI) artifacts 7,10,11,17,18. MRI is a powerful non-invasive tool for medical diagnosis that relies on the nuclear magnetic resonance phenomenon. It presents a high spatial...

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Section: Resultssupporting

confidence: 91%

“…Mo was chosen as a viable alloying element because it is a strong β-stabilizer, has low cytotoxicity 32 , and low magnetic susceptibility 11,25 . The Zr and its alloys were arc-melted in an inert atmosphere using nuclear grade Zr (>99%, residual levels of Hf <5000 ppm and Fe <1000 ppm) and pure Mo (99.95%).…”

Section: Methodsmentioning

confidence: 99%

Appraising the potential of Zr-based biomedical alloys to reduce magnetic resonance imaging artifacts

Suzuki

Campo

Fonseca

et al. 2020

Sci Rep

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“…Their intention was to investigate the properties of β phase, whose precipitates were too small in Zr-2.5Nb alloy, rather than using the Zr-19Nb alloy in practice. Zr-based alloys with retained β phase at room temperature such as Zr-(12-40)Nb [ 26 ], Zr-4Mo-4Sn [ 27 ] or Zr-12Nb-4Sn [ 28 ] are currently studied for manufacturing of medical implants with low elastic modulus and low magnetic susceptibility.…”

Section: Introductionmentioning

confidence: 99%

Novel α + β Zr Alloys with Enhanced Strength

et al. 2021

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Low-alloyed zirconium alloys are widely used in nuclear applications due to their low neutron absorption cross-section. These alloys, however, suffer from limited strength. Well-established guidelines for the development of Ti alloys were applied to design new two-phase ternary Zr alloys with improved mechanical properties. Zr-4Sn-4Nb and Zr-8Sn-4Nb alloys have been manufactured by vacuum arc melting, thermo-mechanically processed by annealing, forging, and aging to various microstructural conditions and thoroughly characterized. Detailed Scanning electron microscopy (SEM) analysis showed that the microstructural response of the alloys is rather similar to alpha + beta Ti alloys. Duplex microstructure containing primary alpha phase particles surrounded by lamellar alpha + beta microstructure can be achieved by thermal processing. Mechanical properties strongly depend on the previous treatment. Ultimate tensile strength exceeding 700 MPa was achieved exceeding the strength of commercial Zr alloys for nuclear applications by more than 50%. Such an improvement in strength more than compensates for the increased neutron absorption cross-section. This study aims to exploit the potential of alpha + beta Zr alloys for nuclear applications.

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“…In the search for new materials for biomedical applications, zirconium gained prominence [1]. Several recent studies in the literature show promising results of mechanical properties, corrosion resistance [2], and biocompatibility [3] of zirconium alloys (Zr-Ti, Zr-Nb, Zr-Mo, Zr-Ta, Zr-Zr-Nb-Zn, Zr-Mo-Zn, Zr-Nb-Ti, and Zr-Al-Fe-Nb) [4][5][6][7][8][9][10][11][12][13] or titanium alloys that have zirconium in their chemical composition (Ti-Ta-Zr, Ti-Nb-Zr-Mn, Ti-Zr-Mo, Ti-Zr-Mo-Ag, Ti-Zr-Mo-Mn, and Ti-Nb-Ta-Zr-Mo) [14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Effect of Titanium Addition on the Structure, Microstructure, and Selected Mechanical Properties of As-Cast Zr-25Ta-xTi Alloys

Kuroda

Pedroso

Grandini

2021

Metals

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Ti alloys are the most used metallic materials in the biomedical field due to their excellent biocompatibility associated with good corrosion resistance in body fluids and relatively low elastic modulus. However, the alloys used in the orthopedic area have an elastic modulus that is 2 to 4 times higher than that of human cortical bone. Searching for new alloys for biomedical applications and with low elastic modulus, zirconium gained prominence due to its attractive properties, especially its biocompatibility. The purpose of this paper is to present novel as-cast alloys of the Zr-25Ta-xTi system and analyze the influence of titanium on the structure, microstructure, microhardness, and elastic modulus of the alloys. The alloys were prepared using an arc-melting furnace. X-ray diffraction measurements and microscopy techniques were used to characterize the crystalline structure and microstructure. From structural and microstructural characterizations, it was observed that titanium acted as an α-stabilizing element since its increase in the precipitation of the orthorhombic α” phase, an intermediate phase from β to α phases, in the alloys. Regarding microhardness measurements, the alloys have higher hardness than pure zirconium due to solid solution hardening that detaches the Zr-25Ta alloy, which has a high hardness value of the precipitation of the ω phase. Among the studied alloys, the Zr-25Ta-25Ti alloy is highlighted, demonstrating the lowest result of modulus of elasticity, which is approximately 2 times higher than the human cortical bone, but many alloys used in the biomedical field, such as pure titanium, have elastic modulus values almost 3 times higher than that of human bone.

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A metastable β-type Zr-4Mo-4Sn alloy with low cost, low Young's modulus and low magnetic susceptibility for biomedical applications

Cited by 22 publications

References 31 publications

Appraising the potential of Zr-based biomedical alloys to reduce magnetic resonance imaging artifacts

Appraising the potential of Zr-based biomedical alloys to reduce magnetic resonance imaging artifacts

Novel α + β Zr Alloys with Enhanced Strength

Effect of Titanium Addition on the Structure, Microstructure, and Selected Mechanical Properties of As-Cast Zr-25Ta-xTi Alloys

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