A method for calculating the magnetic field produced by a coil of any shape

Grainys

2014

IET nanobiotechnol.

Contactless method for manipulation of polar or polarisable micro and nanoscale particles based on the dielectrophoresis force exerted by the induced electric field in high pulsed magnetic field is presented in this study. Finite element method analysis of the magnetic and resulting induced electric fields is carried out. The structure of the magnetic field generator that was based on a controlled frequency spark gap, and the structure of the coil that was used as a load are described. Experimental data showing positive dielectrophoresis on the Jurkat T-lymphoblasts is presented. The study discusses further developments of the technique, its limitations and possible applications.

Section: Magnetic and Induced Electric Fieldsmentioning

confidence: 99%

Contactless dielectrophoretic manipulation of biological cells using pulsed magnetic fields

Grainys

2014

IET nanobiotechnol.

Measurement Science Review

“…Thus, in order to determine the magnetic field distribution of the coil the superposition of the magnetic fields of each wire needs to be evaluated. Magnetic flux density could be evaluated by applying Biot-Savart's law to each wire segment [11]:…”

Section: B Cell Membrane Permeabilizationmentioning

confidence: 99%

Finite Element Method Analysis of Microfluidic Channel with Integrated Dielectrophoresis Electrodes for Biological Cell Permeabilization and Manipulation

Novickij¹,

Grainys²,

Novickij³

2013

The microfluidic channel with a planar inductive microcoil for the cell membrane permeabilization and the integrated planar electrodes for cell dielectrophoretic manipulation is proposed and analyzed in the study. The analyzed setup is based on the dielectrophoretic entrapment of the biological cell followed by membrane permeabilization using high pulsed magnetic field. The finite element method analysis of the DEP force and the generated pulsed magnetic field is performed. Based on finite element method analysis the potential applications of the setup in the fields of drug delivery, biomedicine and biotechnology are discussed.

“…Ansys ® version 12.1 Finite Element Modelling (FEM) software was used in this work. FEM was used to predict the power/heat generation without manufacturing a whole set of microcoils [2,21,28]. Simulated values can then be obtained even for designs that would suppose a low fabrication yield.…”

Section: Introductionmentioning

confidence: 99%

Reusable Embedded Microcoils for Magnetic Nano-Beads Trapping in Microfluidics: Magnetic Simulation and Experiments

et al. 2020

In this study, a microfluidic chip with integrated coil was designed and fabricated for the aim of effectively trapping magnetic nanobeads (Adembeads®, 300 nm) and measuring the chip’s temperature during the working time. In addition, a reversible technique of bonding Polydimethylsiloxane (PDMS) channels was presented. This bonding process used a coating layer of CYTOP®product as a protection, insulation and low-adhesion layer. The reversible packaging technique allows the bottom substrate to be reused, possibly equipped with sensors, and to use a disposable microchannels network. The FE method was employed to calculate the magnetic field and power consumption by the ANSYS® version 12.1 software. Merit factors were defined in order to synthetically represent the ability of the simulated coil to trap beads for a unit power consumption, i.e. a given heat generation. The simulation results propose a new approach to optimize the design criteria in fabricating planar microcoils. The optimal microcoils were fabricated and then used to realize a magnetic immunoassay in a microfluidic chip. The aim was to integrate these microcoils into a lab-on-chip and obtain a fast and highly sensitive biological element detection.