A Method for Cellular Stimulation of Thyroid Transplant for Correction of Thyroid System Function

Abstract

The efficiency of autotransplantation of the thyroid tissue into the greater omentum was demonstrated in experiments on rats. High viability of the transplant and restoration of the hormonal thyroid activity were attained after a single injection of the cell suspension of autologous adherent bone marrow cells directly into the transplant.

Human Leukocyte Antigens

“…Approximately eight in vivo studies exist between 1981 and 2022 [117][118][119][120][121][122][123]. In these studies on thyroid transplantation; auto-and allotransplantation of irradiated thyroid tissue in rats with syngenic rats have been evaluated.…”

“…That in vivo study has a significant role in stem cell and thyroid transplantation [119]. Furthermore, a different study reported the greater omentum feasibility as a transplant site for thyroid tissue via in vivo auto-transplantation model [120]. A more recent study from Wiseman et al described a cell-pouch system for the thyroid tissue and determined the efficiency with viability and thyroid functionality after the subcutaneous transplantation model [121].…”

Modern Views on the Problem of Stem Cells and Potentialities of Their Use in Medicine

“…The efficiency of transplantation of hemopoietic precursors isolated from the blood is higher than that of bone marrow cells [9,14]. Experimental data indicate that MSC mobilized by means of cytokine preparations possess therapeutic activity in situ in some disease, e. g. in myocardial infarction [1,17,18]. All these data indicate that methods of noninvasive manipulations with endogenous stem cells deserve special attention.…”

Pharmacological Regulation of Functional Activity of Stem Cells in Restoration of the Myocardium during the Postinfarction Period

“…On the other hand, new methods for mobilization of the recipient own bone marrow mesenchymal stem cells (MSC) by injection of specific mobilization factors, e. g. granulocytic CSF (G-CSF) and stem cell factor, are intensively developed now. Positive results of preventive and therapeutic injections of these factors to animals with experimental myocardial infarction were reported [2,12,13].…”