A method for peripheral chromatolysis in neurons of trigeminal and dorsal root ganglia, produced in rats by lithium

Levine, Seymour; Saltzman, Arthur; Kumar, Asok

doi:10.1016/j.jneumeth.2003.07.001

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…Since no abnormal swimming behavior was observed, the morphological changes in the Nissl bodies or cell deaths in this study were apparently not severe enough to affect motility in the fish. In mammals, disappearance of Nissl bodies or "chromatolysis" is known to occur after axonal injury (Moon, 2018) or chemical intoxication (Hauw et al, 1988;Levine et al, 2004;Tandrup, 2002). Nissl bodies disappear either from around the nucleus (central chromatolysis) (Hauw et al, 1988;Moon, 2018;Tandrup, 2002) or from the periphery of the cell (peripheral chromatolysis) (Levine et al, 2004); no such clear pattern of Nissl body loss was observed in the present study, and clustering of Nissl substance was only occasionally observed in samples from day 23 in experiment 5.…”

Section: Discussionmentioning

confidence: 99%

“…In mammals, disappearance of Nissl bodies or "chromatolysis" is known to occur after axonal injury (Moon, 2018) or chemical intoxication (Hauw et al, 1988;Levine et al, 2004;Tandrup, 2002). Nissl bodies disappear either from around the nucleus (central chromatolysis) (Hauw et al, 1988;Moon, 2018;Tandrup, 2002) or from the periphery of the cell (peripheral chromatolysis) (Levine et al, 2004); no such clear pattern of Nissl body loss was observed in the present study, and clustering of Nissl substance was only occasionally observed in samples from day 23 in experiment 5. Therefore, the morphological change in neurons caused by FBT treatment is probably reversible if treatment is terminated before cell death.…”

Section: Discussionmentioning

confidence: 99%

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Evaluations of Lethal and Sub-lethal Toxicity of Febantel in the Juvenile Japanese Amberjack <i>Seriola quinqueradiata</i>

et al. 2021

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Febantel (FBT) is a pro-benzimidazole anthelminthic agent. Along with its active metabolite fenbendazole (FBZ), FBT is generally considered a safe drug option to treat various parasites and is commonly used in veterinary medicine due to its efficacy, broad-spectrum activity, and ease of oral administration (Dar et al., 2017;Hardy-Smith et al., 2012). Both compounds are most often used to treat pets and livestock, including mammals, birds, reptiles, and fish (Papich, 2015). In fish, FBT and FBZ have shown efficacy against a broad range of parasite taxa, such as microsporidians, monogeneans, cestodes, and nematodes (

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluations of Lethal and Sub-lethal Toxicity of Febantel in the Juvenile Japanese Amberjack <i>Seriola quinqueradiata</i>

et al. 2021

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“…Central chromatolysis signifies the loss or dispersion of Nissl bodies, starting around the nucleus and extending peripherally. This is the classical neuronal response to axotomy and also occurs after some toxic injuries to neurons [31]. In contrast, peripheral chromatolysis is thought to be much less common; however, it has been reported after axotomy or ischemia in certain species.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effect of Epidurally Administered Lipo-Prostaglandin E1 Agonist in a Rat Spinal Stenosis Model

et al. 2014

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BackgroundA lipo-prostaglandin E1 agonist is effective for the treatment of neurological symptoms of spinal stenosis when administered by an oral or intravenous route. we would like to reveal the therapeutic effect of an epidural injection of lipo-prostaglandin E1 on hyperalgesia in foraminal stenosis.MethodsA total of 40 male Sprague-Dawley rats were included. A small stainless steel rod was inserted into the L5/L6 intervertebral foramen to produce intervertebral foraminal stenosis and chronic compression of the dorsal root ganglia (DRG). The rats were divided into three groups: epidural PGE1 (EP) (n = 15), saline (n = 15), and control (n = 10). In the EP group, 0.15 µg.kg-1 of a lipo-PGE1 agonist was injected daily via an epidural catheter for 10 days from postoperative day 3. In the saline group, saline was injected. Behavioral tests for mechanical hyperalgesia were performed for 3 weeks. Then, the target DRG was analyzed for the degree of chromatolysis, chronic inflammation, and fibrosis in light microscopic images.ResultsFrom the fifth day after lipo-PGE1 agonist injection, the EP group showed significant recovery from mechanical hyperalgesia, which was maintained for 3 weeks (P < 0.05). Microscopic analysis showed much less chromatolysis in the EP group than in the saline or control groups.ConclusionsAn epidurally administered lipo-PGE1 agonist relieved neuropathic pain, such as mechanical hyperalgesia, in a rat foraminal stenosis model, with decreasing chromatolysis in target DRG. We suggest that epidurally administered lipo-PGE1 may be a useful therapeutic candidate for patients with spinal stenosis.

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“…Evaluation of the trigeminal nerve and ganglion is relevant in neurodegenerative diseases such as amyotrophic lateral sclerosis (Sandyk 2006) where neuronal loss is investigated using a mouse model (Yang et al 2011). Other toxicants affecting the trigeminal nerve and ganglion include pyridoxine (vitamin B 6 ) neurotoxicity (Levine and Saltzman 2004), cadmium (Habeebu et al 2001), and lithium toxicity (Levine, Saltzman, and Kumar 2004).…”

Section: Brain Sectionsmentioning

confidence: 99%

Subsite Awareness in Neuropathology Evaluation of National Toxicology Program (NTP) Studies

2013

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This review manuscript is designed to serve as an introductory guide in neuroanatomy for toxicologic pathologists evaluating general toxicity studies. The manuscript provides an overview of approximately 50 neuroanatomical subsites and their functional significance across seven coronal sections of the brain. Also reviewed are three sections of the spinal cord, cranial and peripheral nerves (trigeminal and sciatic respectively), and intestinal autonomic ganglia. The review is limited to the evaluation of hematoxylin and eosin (H&E) stained tissue sections, as light microscopic evaluation of these sections is an integral part of the first-tier toxicity screening of environmental chemicals, drugs, and other agents. Prominent neuroanatomical sites associated with major neurological disorders are noted. This guide, when used in conjunction with detailed neuroanatomic atlases may aid in an understanding of the significance of functional neuroanatomy, thereby improving the characterization of neurotoxicity in general toxicity and safety evaluation studies.

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A method for peripheral chromatolysis in neurons of trigeminal and dorsal root ganglia, produced in rats by lithium

Cited by 7 publications

References 16 publications

Evaluations of Lethal and Sub-lethal Toxicity of Febantel in the Juvenile Japanese Amberjack <i>Seriola quinqueradiata</i>

Evaluations of Lethal and Sub-lethal Toxicity of Febantel in the Juvenile Japanese Amberjack <i>Seriola quinqueradiata</i>

Therapeutic Effect of Epidurally Administered Lipo-Prostaglandin E1 Agonist in a Rat Spinal Stenosis Model

Subsite Awareness in Neuropathology Evaluation of National Toxicology Program (NTP) Studies

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