A method of elevated temperatures coupled with magnetic stirring to predict real time release from long acting progesterone PLGA microspheres

Ye, Mingzhu; Duan, Hongliang; Yao, Lixia; Fang, Yicheng; Zhang, Xiaoyu; Dong, Ling; Yang, Feifei; Yang, Xinggang; Pan, Weisan

doi:10.1016/j.ajps.2018.05.010

Cited by 10 publications

(7 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, the release of the drug away from the release surfaces, the water or the medium, takes longer to migrate through the thickness of the polymer [2,35]. This study is applicable in all cases of drug delivery as stents, ear pads, patches, and contact lenses [6,34,[36][37][38][39][40][41]. In all these cases, some parameters have importance like the geometry of the drug holders, glass transition temperature, viscosity, drug percentage, drug type, coating thickness, and release kinetics [6,28].…”

Section: Introductionmentioning

confidence: 89%

See 1 more Smart Citation

In vitro study of drug release from various loaded polyurethane samples and subjected to different non-pulsed flow rates

Abbasnezhad

Shirinbayan

Tcharkhtchi

et al. 2020

Journal of Drug Delivery Science and Technology

View full text Add to dashboard Cite

Drug-eluting implants with a polymeric matrix are currently widely used and the interest of modeling their behavior is increasing. This article aims to present preliminary results of an in vitro under steady flow, study the behavior of drug-loaded polyurethane samples used as drug delivery matrices. Polyisocyanate and polyol synthesis supplied the polyurethane studied in this work. A molding and heat at 50°C for about 30 min make it possible to prepare films from these components. The prepared samples are placed in the impermeable Plexiglas tube and they are in contact with the medium (distilled water). Tests have been performed without flow and three other cases with steady flow, at a temperature of 37°C. The substance active incorporated in these films, as the drug, for carrying out the release tests is the C 20 H 24 C 12 N 2 O 3. This drug supplied in granular form is composed of a mixture in the following proportions, 15 mg of diclofenac epolamine and 50 mg of diclofenac-sodium. Four sample variants were carefully prepared: pure-PU and PU loaded in a mass ratio of 10, 20 or 30%. Weighing, DSC, FT-IR, and DMTA are the methods used to analyze the samples. In addition, SEM micrographs are used to explore qualitatively the microstructure during the release tests. The kinetics in vitro of the drug release and water absorption by the polyurethane films are discussed in detail. The results show that these two quantities depend on the initial drug loading and the flow rate value, as a function of the in vitro incubation time.

show abstract

Section: Introductionmentioning

confidence: 89%

“…However, in Ref. [34] Ye et al found that the increase in temperature significantly changed the drug release profile from PLGA progesterone microspheres, because of mechanism change. In the diffusion-controlled system, the drug is released through the pores, polymeric membranes and chains.…”

Section: Introductionmentioning

confidence: 99%

In vitro study of drug release from various loaded polyurethane samples and subjected to different non-pulsed flow rates

Abbasnezhad

Shirinbayan

Tcharkhtchi

et al. 2020

Journal of Drug Delivery Science and Technology

View full text Add to dashboard Cite

show abstract

“…To monitor the amount of drug released from the microparticles, a sample for analysis is prepared by separating the supernatant from the precipitated microparticles after centrifugation. When the drug is stable in the release medium, the supernatant is periodically taken and the filtered samples are analyzed by spectrophotometric or chromatographic methods [ 32 , 33 ]. For drugs that are unstable in the release medium, residual microparticles are recovered and the drug remaining in the microparticles is analyzed to indirectly determine the amount of drug released [ 34 , 35 ].…”

Section: In Vitro Drug Release Testing Methodsmentioning

confidence: 99%

Recent Progress in Drug Release Testing Methods of Biopolymeric Particulate System

et al. 2021

View full text Add to dashboard Cite

Biopolymeric microparticles have been widely used for long-term release formulations of short half-life chemicals or synthetic peptides. Characterization of the drug release from microparticles is important to ensure product quality and desired pharmacological effect. However, there is no official method for long-term release parenteral dosage forms. Much work has been done to develop methods for in vitro drug release testing, generally grouped into three major categories: sample and separate, dialysis membrane, and continuous flow (flow-through cell) methods. In vitro drug release testing also plays an important role in providing insight into the in vivo performance of a product. In vitro release test with in vivo relevance can reduce the cost of conducting in vivo studies and accelerate drug product development. Therefore, investigation of the in vitro–in vivo correlation (IVIVC) is increasingly becoming an essential part of particulate formulation development. This review summarizes the principles of the in vitro release testing methods of biopolymeric particulate system with the recent research articles and discusses their characteristics including IVIVC, accelerated release testing methods, and stability of encapsulated drugs.

show abstract

“…PLGA-based DDSs include morphologies such as microparticles or microspheres [ 40 ], nanofibers [ 41 ], films [ 42 ], foams [ 43 ], gels [ 44 ], nanoparticles [ 45 , 46 ], among others [ 30 , 35 ]. Being of a size that allows them to navigate freely through the body and remain for a long period of time in the blood circulatory system, nanoparticles, especially polymeric ones, have shown great potential as DDS [ 47 , 48 ].…”

Section: Introductionmentioning

confidence: 99%

“…The initial stage is due to the presence of non-encapsulated drug molecules on the surface, drug particles attached to the surface of the nanoparticle [ 61 ], diffusion of the active compound through the polymeric matrix, diffusion of the encapsulated agent through water-filled pores, penetration of the surrounding medium from the surface to the center of the nanoparticle and activation of the hydrolytic degradation of the PLGA [ 58 , 62 ]. Initial hydrolytic degradation of the polymer and diffusion of the drug through the polymer matrix are also present, although their impact is minor [ 30 , 40 , 58 ]. The hydrophilic or hydrophobic nature of the encapsulating agent and its molecular weight also play an important role in this phase [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative statistical analysis of the release kinetics models for nanoprecipitated drug delivery systems based on poly(lactic-co-glycolic acid)

et al. 2022

View full text Add to dashboard Cite

Poly(lactic-co-glycolic acid) is one of the most used polymers for drug delivery systems (DDSs). It shows excellent biocompatibility, biodegradability, and allows spatio-temporal control of the release of a drug by altering its chemistry. In spite of this, few formulations have reached the market. To characterize and optimize the drug release process, mathematical models offer a good alternative as they allow interpreting and predicting experimental findings, saving time and money. However, there is no general model that describes all types of drug release of polymeric DDSs. This study aims to perform a statistical comparison of several mathematical models commonly used in order to find which of them best describes the drug release profile from PLGA particles synthesized by nanoprecipitation method. For this purpose, 40 datasets extracted from scientific articles published since 2016 were collected. Each set was fitted by the models: order zero to fifth order polynomials, Korsmeyer-Peppas, Weibull and Hyperbolic Tangent Function. Some data sets had few observations that do not allow to apply statistic test, thus bootstrap resampling technique was performed. Statistic evidence showed that Hyperbolic Tangent Function model is the one that best fit most of the data.

show abstract

A method of elevated temperatures coupled with magnetic stirring to predict real time release from long acting progesterone PLGA microspheres

Cited by 10 publications

References 42 publications

In vitro study of drug release from various loaded polyurethane samples and subjected to different non-pulsed flow rates

In vitro study of drug release from various loaded polyurethane samples and subjected to different non-pulsed flow rates

Recent Progress in Drug Release Testing Methods of Biopolymeric Particulate System

Comparative statistical analysis of the release kinetics models for nanoprecipitated drug delivery systems based on poly(lactic-co-glycolic acid)

Contact Info

Product

Resources

About