Finite element modeling (FEM) of machining has recently become the most attractive computational tool to predict and optimize metal cutting processes. High-speed computers and advanced finite element code have offered the possibility of simulating complex machining processes such as turning, milling, and drilling. The use of an accurate constitutive law is very important in any metal cutting simulation. It is desirable that a constitutive law could completely characterize the thermovisco-plastic behavior of the machined materials at high strain rate. The most commonly used law is that of Johnson and Cook (JC) which combines the effect of strains, strain rates, and temperatures. Unfortunately, the different coefficients provided in the literature for a given material are not reliable since they affect significantly the predicted results (cutting forces, temperatures, residual stresses, etc.). In the present work, five different sets of JC are determined based on orthogonal machining tests. These five sets are then used in finite element modeling to simulate the machining behavior of Al2024-T3 alloy. The effects of these five different sets of JC constants on the numerically predicted cutting forces, chip morphology, and tool-chip contact length are the subject of a comparative investigation. It is concluded that these predicted cutting parameters are sensitive to the material constants.