A MgFe‐LDH Nanosheet‐Incorporated Smart Thermo‐Responsive Hydrogel with Controllable Growth Factor Releasing Capability for Bone Regeneration

Abstract

Therefore, we have successfully constructed the organic-inorganic thermo-responsive CS-L hydrogel system containing the dual-GFs and bioactive metal ions, which exhibited excellent angiogenic and osteogenic properties and results in the satisfied bone regeneration performance.

Smart Hydrogels for Bone Reconstruction via Modulating the Microenvironment

“…Silk fibroin is a natural protein extracted from Bombyx mori silk cocoons. It is a potential candidate for bone regeneration due to its excellent mechanical properties [ 48 , 49 ]. Under various treatments, including thermal, sonication, vortexing, pH, and alcohol treatments, a silk fibroin solution can be gelatinized [ 50 ].…”

Nanosheet–hydrogel composites: from preparation and fundamental properties to their promising applications

“…biocompatibility, hydrophilicity, and porosity). [26][27][28] Moreover, nanosheets can endow hydrogels with the responsivity to specific environmental stimuli by utilizing unique mechanical, optical, and biological characteristics, making them ideal for ''smart'' materials. [29][30][31] a Department of Physics, Research Institute for Biomimetics and Soft Matter, Fujian So far, different forms of nanosheets, such as montmorillonite (MMT), transition metal carbides and nitrides (MXene), 32 graphene oxide (GO), 33 layered double hydroxides (LDH), 34 titanate(IV) nanosheets, 35,36 and controllable activated nanoplatelets, have been introduced into hydrogels, which offer a wealth of opportunities for modulating the properties and enriching the functions of hydrogels.…”

“…biocompatibility, hydrophilicity, and porosity). 26–28 Moreover, nanosheets can endow hydrogels with the responsivity to specific environmental stimuli by utilizing unique mechanical, optical, and biological characteristics, making them ideal for “smart” materials. 29–31…”

Monolayer LDH Nanosheets with Ultrahigh ICG Loading for Phototherapy and Ca2+-Induced Mitochondrial Membrane Potential Damage to Co-Enhance Cancer Immunotherapy

“…Generally, PDT alone cannot achieve a satisfactory immunotherapeutic effect . Therefore, PDT combined with other therapeutic modalities can amplify the advantages and offset the disadvantages. , For example, mitochondrial membrane potential damage (MMPD) can not only induce tumor cell apoptosis but also reduce oxygen consumption by mitochondria, thereby enhancing the PDT effect. − Meanwhile, photothermal therapy (PTT) is thought to promote in situ the release of tumor-derived protein antigens and other immune stimulants by inducing tumor cell necrosis. ,, …”

“…24−26 Meanwhile, photothermal therapy (PTT) is thought to promote in situ the release of tumor-derived protein antigens and other immune stimulants by inducing tumor cell necrosis. 11,27,28 Mitochondria play a key role in energy generation and apoptosis. 29 Ca 2+ overexpression in mitochondria may cause the loss of mitochondrial membrane potential (MMP) and increased permeability of the mitochondrial membrane, thereby reducing oxygen consumption.…”