A Micellar-Hydrogel Nanogrid from a UV Crosslinked Inulin Derivative for the Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs

Mandracchia, Delia; Trapani, Adriana; Perteghella, Sara; Franco, Cinzia Di; Torre, Maria Luisa; Calleri, Enrica; Tripodo, Giuseppe

doi:10.3390/pharmaceutics10030097

Cited by 16 publications

(9 citation statements)

References 31 publications

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“…(b,c)]. Similar spherical structures have been reported in many other micelle‐crosslinked hydrogels and recognized as the results of microphase separation of hydrophobic association domains from the polymer matrix. Herein, the appearance of spherical structures was related to the separation of F127DA micelles from the polyacrylamide (PAAm) matrix.…”

Section: Resultssupporting

confidence: 76%

Effect of solvent–matrix interactions on structures and mechanical properties of micelle‐crosslinked gels

Gao

et al. 2019

J Polym Sci B Polym Phys

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Previous studies on hydrogels crosslinked by acrylated PEO99–PPO65–PEO99 triblock copolymer (F127DA) micelles demonstrate outstanding strength and toughness, which is attributed to the efficient energy dissipation through the hydrophobic association in the micelles. The current study further focuses on how the solvent property affects the structures and the mechanical properties of F127DA micelle crosslinked polyacrylamide gels. Binary solvents comprised of dimethyl sulfoxide (DMSO) and water are used to adjust the polymer/solvent interactions, which consequently tune the conformations of the polymer chains in the network. The presence of DMSO significantly decreases the strength but increased the stretchability of the gels, whereas the overall tensile toughness remained unchanged. In situ small‐angle X‐ray scattering measurements reveal the deformation of micelles along with the stretching direction. A structure evolution mechanism upon solvent change is proposed, according to the experimental observations, to explain influence of solvent quality on the mechanical properties of the micelle‐crosslinked gels. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2019, 57, 473–483

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Section: Resultssupporting

confidence: 76%

Effect of solvent–matrix interactions on structures and mechanical properties of micelle‐crosslinked gels

Gao

et al. 2019

J Polym Sci B Polym Phys

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“…These particles are smaller than the ξ H of F127DA micelles formed in DMSO solutions. Similar formation of particles has been observed in other micellecrosslinked hydrogels and recognized as microphase separation structures [25][26][27]. Here, the presence of DMSO promotes microphase separation of micelles from PAAm networks.…”

Section: Effect Of Solvent On Structures and Propertiessupporting

confidence: 80%

Triblock Copolymer Micelle-Crosslinked Hydrogels

2020

Self-Healing and Self-Recovering Hydrogels

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This chapter reviews the preparation, structures, properties, and applications of tough and responsive hydrogels crosslinked by triblock copolymer micelles. An amphiphilic triblock copolymer, Pluronic F127, is functionalized with reactive groups. The functional F127 chains form polyfunctional micelles in aqueous solution, which are used for reaction with hydrophilic monomers or polymer chains to form hydrophobically crosslinked network. Free radical polymerization, host-guest interaction, and dynamic bonds have been utilized to connect the polymer chains with the reactive micelle coronae. The obtained polymer hydrogels show outstanding strength and toughness, with the micelles serving as energy dissipation centers. The structural evolution and energy dissipation mechanisms have been investigated in detail. By incorporating functional monomers into the network, a series of functional hydrogels responsive to pH, salt, electric field, and temperature have been developed. The hydrogels have been utilized as building blocks to fabricate soft actuators, shape-morphing devices, and biomaterials for tissue repair.

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“…In addition, 22 wt % copolymer has an advantage for ease-of-use to form a gel in response to body temperature without the use of UV cross-linking or the addition of crosslinking components that are toxic for cells and tissues. 46,47 Effects of 22 wt % Copolymer with and without Fibrinogen on HAEC Viability and Proliferation. Biocompatibility of 22 wt % copolymers with and without fibrinogen was assessed by a human aortic endothelial cell (HAEC) viability test.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Evaluation of Viscoelastic Properties, Blood Coagulation, and Cellular Responses of a Temperature-Sensitive Gel for Hemostatic Application

Jun

Millican

Sherwood

et al. 2020

ACS Appl. Bio Mater.

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Hemorrhagic blood loss from traumatic injury is the leading cause of death in severe accidents and combat injuries. Treating and stopping blood loss in a timely and effective manner is essential for the survival of the patient. Currently, QuikClot and dry fibrin sealant dressing are well-known approaches for hemostatic treatment. However, these dressings have limitations in slowing blood loss such as being brittle, low blood absorption, and a poor sealant of the injury site. Temperature-sensitive gels may have potential as a platform for delivery of coagulation factors to improve hemostasis and wound sealing in the treatment of traumatic injuries. Here, we developed a temperature-sensitive triblock copolymer (poly ethylene oxide (PEO)-poly propylene oxide (PPO)-poly ethylene oxide (PEO)) containing fibrinogen to promote blood coagulation through gel formation at body temperature. This temperature sensitive solution-to-gel (sol–gel) transition does not require cross-linking agents or UV photoinitiation. We determined that 22 wt % (weight percent) copolymers with and without fibrinogen was the maximum concentration for sol–gel transition at body temperature. Rheology results further confirmed this sol–gel transition of 22 wt % copolymers at body temperature. We showed that fibrinogen itself promoted blood coagulation. Additionally, 22 wt % copolymer with fibrinogen successfully demonstrated stable blood coagulation within the gel compared to 22 wt % copolymer without fibrinogen. Twenty-two weight percent copolymers with and without fibrinogen also exhibited excellent biocompatibility based on cell viability, proliferation, and morphology analysis. In addition, treatment of 22 wt % copolymers did not stimulate pro-inflammatory TNF-α production from differentiated human monocytes. Our results suggest that 22 wt % of a temperature-sensitive copolymer gel containing fibrinogen has great potential as a hemostatic agent stimulating coagulation and providing immediate wound coverage for protection through a sol–gel transition at body temperature.

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A Micellar-Hydrogel Nanogrid from a UV Crosslinked Inulin Derivative for the Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs

Cited by 16 publications

References 31 publications

Effect of solvent–matrix interactions on structures and mechanical properties of micelle‐crosslinked gels

Effect of solvent–matrix interactions on structures and mechanical properties of micelle‐crosslinked gels

Triblock Copolymer Micelle-Crosslinked Hydrogels

Evaluation of Viscoelastic Properties, Blood Coagulation, and Cellular Responses of a Temperature-Sensitive Gel for Hemostatic Application

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