2015
DOI: 10.1039/c5an01193k
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A microchip integrating cell array positioning with in situ single-cell impedance measurement

Abstract: This paper presents a novel microarray chip integrating cell positioning with in situ, real-time and long-time impedance measurement on a single cell. The microchip integrates a plurality of quadrupole-electrode units (termed positioning electrodes) patterned into an array with pairs of planar electrodes (termed measuring electrodes) located at the centers of each quadrupole-electrode unit. The positioning electrodes are utilized to trap and position living cells onto the measuring electrodes based on negative… Show more

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Cited by 31 publications
(35 citation statements)
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“…This kind of method by using dielectrophoresis‐assisted clinical diagnosis has been deeply studied and applied by many researchers .…”
Section: Cell Manipulation Approaches By Dielectrophoresismentioning
confidence: 99%
“…This kind of method by using dielectrophoresis‐assisted clinical diagnosis has been deeply studied and applied by many researchers .…”
Section: Cell Manipulation Approaches By Dielectrophoresismentioning
confidence: 99%
“…7, an equivalent circuit was proposed based on the lEoN structure on the condition that the lEoN was immersed in the bio-tissues. [28][29][30][31][32][33][34] The total sensor output is a combination of the resistance (R) and capacitance (C) of parylene C and tissue samples, double layer capacitance, and constant phase element (CPE).…”
Section: -6mentioning
confidence: 99%
“…26 The solution in the cell-flowing channel is expressed in terms of resistance (R sol ), which is connected in series with a single constant phase element (CPE) corresponding to the double layer impedance. 25,27 R seal represents seal resistance bypassing the trapped cell. 25,28 Parasitic capacitance (C p ) is also included because a parasitic effect exists in a microdevice and measurement system.…”
Section: A Electrical Impedance Analysis Of Cells With Agingmentioning
confidence: 99%
“…25,28 Parasitic capacitance (C p ) is also included because a parasitic effect exists in a microdevice and measurement system. 25,29 The best-fitting parameters from 1 kHz to 1 MHz were extracted using non-linear least squares fitting in the Gamry Analyst software. Initially, the impedance data without cells were used to calculate C p .…”
Section: A Electrical Impedance Analysis Of Cells With Agingmentioning
confidence: 99%
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