A microdialysis technique for continuous subcutaneous glucose monitoring in diabetic patients (part 1)

Poscia, Alessandro; Mascini, Marco; Moscone, Danila; Luzzana, M.; Caramenti, G.; Cremonesi, Paola; Valgimigli, Francesco; Bongiovanni, Cristiana; Varalli, M

doi:10.1016/s0956-5663(02)00216-6

Cited by 91 publications

(60 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the use of a validated continuous glucose-monitoring system (Maran et al, 2002;Poscia et al, 2003;Varalli et al, 2003;Maran et al, 2004;Wentholt et al, 2005), we assessed 24 h blood glucose concentrations in long-standing type 2 diabetes patients under strict dietary standardization but otherwise free-living conditions. Despite a healthy, balanced diet and the continued use of oral blood glucoselowering medication (ADA 2006), these type 2 diabetes patients showed substantial hyperglycemia throughout the greater part of the day.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Protein hydrolysate co-ingestion does not modulate 24 h glycemic control in long-standing type 2 diabetes patients

et al. 2007

View full text Add to dashboard Cite

Objective: Evaluate the efficacy of protein hydrolysate co-ingestion as a dietary strategy to improve blood glucose homeostasis under free-living conditions in long-standing type 2 diabetes patients. Methods: A total of 13 type 2 diabetes patients were enrolled in a randomized, double-blind cross-over design and studied on two occasions for 40 h under strict dietary standardization but otherwise normal, free-living conditions. In one trial, subjects ingested a protein hydrolysate (0.4 g kg À1 bw casein hydrolysate, PRO) with every main meal. In the other trial, a placebo was ingested (PLA). Blood glucose concentrations were assessed by continuous glucose monitoring. Results: Average 24 h glucose concentrations were similar between the PLA and the PRO trials (8.970.8 vs 9.270.7 mmol l À1 , respectively). Hyperglycemia (glucose concentrations 410 mmol l À1 ) was experienced 3479% of the time (872 h per 24 h) in the PLA trial. Protein hydrolysate co-ingestion with each main meal (PRO) did not reduce the prevalence of hyperglycemia (39710%, 972 h per 24 h; P ¼ 0.2). Conclusion: Co-ingestion of a protein hydrolysate with each main meal does not improve glucose homeostasis over a 24 h period in long-standing type 2 diabetes patients.

show abstract

Section: Discussionmentioning

confidence: 99%

“…A detailed description of the device is provided elsewhere (Poscia et al, 2003;Varalli et al, 2003).…”

Section: Continuous Glucose Monitoring Systemmentioning

confidence: 99%

Protein hydrolysate co-ingestion does not modulate 24 h glycemic control in long-standing type 2 diabetes patients

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Poscia and colleagues found the GlucoDay RAD to be 20% in rabbits (19) and 15% in a mixed type 1/type 2 diabetic population (20).…”

Section: Technologies -Five Cgms Have Been Approved By the Us Food mentioning

confidence: 99%

Continuous Glucose Monitoring

2005

View full text Add to dashboard Cite

“…Standard techniques such as immunoassays, gel electrophoresis and nuclear magnetic resonance typically cannot be performed in live cells and tissues, or at least they require preparation steps that inhibit real-time measurements [1]. Instead, electrochemical sensing based on oxidases is suitable for real-time monitoring of metabolites, such as glucose [2] and lactate [3].…”

Section: Introductionmentioning

confidence: 99%

Targeting of multiple metabolites in neural cells monitored by using protein-based carbon nanotubes

Boero

Carrara

Vecchio

et al. 2011

Sensors and Actuators B: Chemical

View full text Add to dashboard Cite

a b s t r a c tMicrodevices dedicated to monitor metabolite levels have recently enabled many applications in the field of cell analysis, to monitor cell growth and development of numerous cell lines. By combining the traditional technology used for electrochemical biosensors with nanoscale materials, it is possible to develop miniaturized metabolite biosensors with unique properties of sensitivity and detection limit. In particular, enzymes tend to adsorb onto carbon nanotubes and their optical or electrical activity can perturb the electronic properties. In the present work we propose multi-walled carbon nanotube-based biosensors to monitor a cell line highly sensitive to metabolic alterations, in order to evaluate lactate production and glucose uptake during different cell states. We achieve sensors for both lactate and glucose, with sensitivities of 40.1 A mM −1 cm −2 and 27.7 A mM −1 cm −2 , and detection limits of 28 M and 73 M, respectively. This nano-biosensing technology is used to provide new information on cell line metabolism during proliferation and differentiation, which are unprecedented in cell biology.

show abstract

A microdialysis technique for continuous subcutaneous glucose monitoring in diabetic patients (part 1)

Cited by 91 publications

References 14 publications

Protein hydrolysate co-ingestion does not modulate 24 h glycemic control in long-standing type 2 diabetes patients

Protein hydrolysate co-ingestion does not modulate 24 h glycemic control in long-standing type 2 diabetes patients

Continuous Glucose Monitoring

Targeting of multiple metabolites in neural cells monitored by using protein-based carbon nanotubes

Contact Info

Product

Resources

About