Protein hydrolysate co-ingestion does not modulate 24 h glycemic control in long-standing type 2 diabetes patients

Abstract

Objective: Evaluate the efficacy of protein hydrolysate co-ingestion as a dietary strategy to improve blood glucose homeostasis under free-living conditions in long-standing type 2 diabetes patients. Methods: A total of 13 type 2 diabetes patients were enrolled in a randomized, double-blind cross-over design and studied on two occasions for 40 h under strict dietary standardization but otherwise normal, free-living conditions. In one trial, subjects ingested a protein hydrolysate (0.4 g kg À1 bw casein hydrolysate, PRO) with every main meal. In the other trial, a placebo was ingested (PLA). Blood glucose concentrations were assessed by continuous glucose monitoring. Results: Average 24 h glucose concentrations were similar between the PLA and the PRO trials (8.970.8 vs 9.270.7 mmol l À1 , respectively). Hyperglycemia (glucose concentrations 410 mmol l À1 ) was experienced 3479% of the time (872 h per 24 h) in the PLA trial. Protein hydrolysate co-ingestion with each main meal (PRO) did not reduce the prevalence of hyperglycemia (39710%, 972 h per 24 h; P ¼ 0.2). Conclusion: Co-ingestion of a protein hydrolysate with each main meal does not improve glucose homeostasis over a 24 h period in long-standing type 2 diabetes patients.

Insulinotropic and Muscle Protein Synthetic Effects of Branched-Chain Amino Acids: Potential Therapy for Type 2 Diabetes and Sarcopenia

“…In these studies the effects of protein modulation (protein only, and protein combined with free leucine) were determined on the prevalence of hyperglycemia in well-controlled type 2 diabetes patients as measured with continuous glucose monitoring. Whereas a protein/leucine mixture was able to lower the prevalence of hyperglycemia by 26% [74], the same absolute amount of protein (without free leucine) did not results in a further improvement of glycemic control [75]. These results extend on previous findings [46,76,77], and imply that nutritional interventions with protein, and leucine in particular can represent an effective strategy to reduce postprandial blood glucose excursions.…”

Prevalence of daily hyperglycemia in obese type 2 diabetic men compared with that in lean and obese normoglycemic men: effect of consumption of a sucrose-containing beverage

“…In accordance, we applied continuous glucose monitoring to show that postprandial hyperglycemic blood glucose excursions are prevalent throughout the greater part of the day, even in well-controlled, type 2 diabetic subjects using oral blood glucose-lowering medication (11,14). Consequently, it became evident that, even in the presence of normal hemoglobin A 1c values, large perturbations in postprandial blood glucose concentrations can be prevalent throughout the day (10,15).…”

Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes

“…Co‐ingestion of additional leucine increases postprandial insulin release and stimulates blood glucose disposal. Several studies support the hypothesis that administration of protein and additional leucine represents an effective dietary strategy to improve glycemic control in patients with type 2 diabetes 11–16 . This review article evaluates whether leucine represents an effective pharmaconutrient in the prevention and treatment of sarcopenia and type 2 diabetes.…”