Prevalence of daily hyperglycemia in obese type 2 diabetic men compared with that in lean and obese normoglycemic men: effect of consumption of a sucrose-containing beverage

Manders, Ralph; Pennings, Bart; Beckers, Cindy P G; Aipassa, Tamara I; Loon, Luc J. C. van

doi:10.3945/ajcn.2008.27072

Cited by 17 publications

(11 citation statements)

References 47 publications

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“…2). Nonetheless, 9 ± 3% of hyperglycaemia is still threefold higher than the hyperglycaemic episodes that were previously recorded in overweight, normoglycaemic men using a comparable standardised diet [3, 22]. Evidently, there is need for effective treatment strategies in both prediabetic individuals, type 2 diabetic patients using OGLMs, and long-standing insulin-treated type 2 diabetic patients to reduce the prevalence of hyperglycaemia, and thereby improve daily glycaemic control.…”

Section: Discussionmentioning

confidence: 99%

Both resistance- and endurance-type exercise reduce the prevalence of hyperglycaemia in individuals with impaired glucose tolerance and in insulin-treated and non-insulin-treated type 2 diabetic patients

et al. 2011

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Aims/hypothesisThe present study compares the impact of endurance- vs resistance-type exercise on subsequent 24 h blood glucose homeostasis in individuals with impaired glucose tolerance (IGT) and type 2 diabetes.MethodsFifteen individuals with IGT, 15 type 2 diabetic patients treated with exogenous insulin (INS), and 15 type 2 diabetic patients treated with oral glucose-lowering medication (OGLM) participated in a randomised crossover experiment. Participants were studied on three occasions for 3 days under strict dietary standardisation, but otherwise free-living conditions. Blood glucose homeostasis was assessed by ambulatory continuous glucose monitoring over the 24 h period following a 45 min session of resistance-type exercise (75% one repetition maximum), endurance-type exercise (50% maximum workload capacity) or no exercise at all.ResultsAverage 24 h blood glucose concentrations were reduced from 7.4 ± 0.2, 9.6 ± 0.5 and 9.2 ± 0.7 mmol/l during the control experiment to 6.9 ± 0.2, 8.6 ± 0.4 and 8.1 ± 0.5 mmol/l (resistance-type exercise) and 6.8 ± 0.2, 8.6 ± 0.5 and 8.5 ± 0.5 mmol/l (endurance-type exercise) over the 24 h period following a single bout of exercise in the IGT, OGLM and INS groups, respectively (p < 0.001 for both treatments). The prevalence of hyperglycaemia (blood glucose >10 mmol/l) was reduced by 35 ± 7 and 33 ± 11% over the 24 h period following a single session of resistance- and endurance-type exercise, respectively (p < 0.001 for both treatments).Conclusions/interpretationA single session of resistance- or endurance-type exercise substantially reduces the prevalence of hyperglycaemia during the subsequent 24 h period in individuals with IGT, and in insulin-treated and non-insulin-treated type 2 diabetic patients. Both resistance- and endurance-type exercise can be integrated in exercise intervention programmes designed to improve glycaemic control.Trial registration:Clinicaltrials.gov NCT00945165Funding:The Netherlands Organization for Health Research and Development (ZonMw, the Netherlands).

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Section: Discussionmentioning

confidence: 99%

Both resistance- and endurance-type exercise reduce the prevalence of hyperglycaemia in individuals with impaired glucose tolerance and in insulin-treated and non-insulin-treated type 2 diabetic patients

et al. 2011

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“…Obesity may lead to an insulin resistant state in the liver, muscle cells and adipose tissue, resulting in distorted function of insulin targeted cells and buildup of macrophages that secrete pro-inflammatory mediators. The excessive consumption of high glycaemic diets and sucrose enriched soft drinks may further augment the incidence of dysglycaemic episodes (Manders, Pennings, Beckers, Aipassa, & van Loon, 2009). Various studies have shown that high fibre diets being statiogenic add viscosity and bulk to the meals thereby slowing the gastric emptying.…”

Section: Hypoglycaemic Facetsmentioning

confidence: 99%

Prebiotics, gut microbiota and metabolic risks: Unveiling the relationship

Yasmin

Butt

Afzaal

et al. 2015

Journal of Functional Foods

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“…The glycemic instability is a severely underestimated problem in patients with type 2 diabetes. Even in patients whose type 2 diabetes is well controlled with oral blood‐glucose‐lowering medication, hyperglycemia is still prevalent throughout the greater part of the day 95,96 . The capacity to maintain good glycemic control is generally evaluated on the basis of the glycemic and insulinemic response to the ingestion of a single bolus of carbohydrate 97 .…”

Section: Leucine As a Pharmaconutrient In Patients With Type 2 Diabetesmentioning

confidence: 99%

“…Even in patients whose type 2 diabetes is well controlled with oral blood-glucoselowering medication, hyperglycemia is still prevalent throughout the greater part of the day. 95,96 The capacity to maintain good glycemic control is generally evaluated on the basis of the glycemic and insulinemic response to the ingestion of a single bolus of carbohydrate. 97 However, it should be noted that carbohydrate is not the only macronutrient that strongly increases endogenous insulin release following food intake.…”

Section: Leucine As a Pharmaconutrient In Patients With Type 2 Diabetesmentioning

confidence: 99%

Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes

2011

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Amino acids function as precursors for de novo protein synthesis. In addition, however, they play a key role as nutritional signals that regulate multiple cellular processes. There is ample in vitro and in vivo evidence showing that muscle tissue responds to increases in amino acid availability via signal transduction pathways that are also regulated by insulin, glucagon, growth hormone, and insulin growth factor 1. The increased amino acid availibility results in the upregulation of mRNA translation, thereby increasing muscle protein synthesis, which, in turn, leads to greater net muscle protein accretion. These findings have been particularly pronounced for the amino acid leucine. Furthermore, leucine has the ability to act as a strong insulin secretagogue. Consequently, it has been suggested that leucine represents an effective pharmaconutrient for the prevention and treatment of sarcopenia and type 2 diabetes. In accordance, recent in vivo studies in humans show that free leucine ingestion can reverse the blunted response of muscle protein synthesis to amino acid/protein intake in the elderly. Although short-term studies suggest that leucine supplementation can stimulate muscle mass accretion in the elderly, there are no long-term nutritional intervention studies to confirm this or the other proposed benefits of leucine as a pharmaconutrient.

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Prevalence of daily hyperglycemia in obese type 2 diabetic men compared with that in lean and obese normoglycemic men: effect of consumption of a sucrose-containing beverage

Cited by 17 publications

References 47 publications

Both resistance- and endurance-type exercise reduce the prevalence of hyperglycaemia in individuals with impaired glucose tolerance and in insulin-treated and non-insulin-treated type 2 diabetic patients

Both resistance- and endurance-type exercise reduce the prevalence of hyperglycaemia in individuals with impaired glucose tolerance and in insulin-treated and non-insulin-treated type 2 diabetic patients

Prebiotics, gut microbiota and metabolic risks: Unveiling the relationship

Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes

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