A microfluidic chip using Au@SiO2 array–based highly SERS-active substrates for ultrasensitive detection of dual cervical cancer–related biomarkers

Gu, Yingyan; Li, Zhiyue; Ge, Shengjie; Mao, Yu; Gu, Yuexing; Cao, Xiaowei; Lü, Dan

doi:10.1007/s00216-022-04296-w

Cited by 11 publications

(5 citation statements)

References 39 publications

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“…Such a test allows the detection of CEA and SCCA, in which the LOD in human serum was 0.36 pg mL À 1 and 0.37 pq mL À 1 , respectively. [182] Ag NPs are also used in cancer therapy. The conducted research shows that Ag@SiO 2 nanostructures can be a potential replacement for currently used photosensitizers used in PDT therapy.…”

Section: Application In Therapy and Diagnosis Of Cancermentioning

confidence: 99%

“…The biosensor constructed in this way is characterized by extraordinary accuracy and sensitivity and also enables the detection of both biomarkers in parallel. Such a test allows the detection of CEA and SCCA, in which the LOD in human serum was 0.36 pg mL −1 and 0.37 pq mL −1 , respectively [182] . Ag NPs are also used in cancer therapy.…”

Section: Medical Application Of Ag/au@silica Core‐shell Nanostructuresmentioning

confidence: 99%

See 1 more Smart Citation

Medical Applications of Silver and Gold Nanoparticles and Core‐Shell Nanostructures Based on Silver or Gold Core: Recent Progress and Innovations

Kowalska,

Adamska,

Grobelna

2024

ChemMedChem

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Nanoparticles (NPs) of noble metals such as silver (Ag NPs) or gold (Au NPs) draw the attention of scientists looking for new compounds to use in medical applications. Scientists have used metal NPs because of their easy preparation, biocompatibility, ability to influence the shape and size or modification, and surface functionalization. However, to fully use their capabilities, both the benefits and their potential threats should be considered. One possibility to reduce the potential threat and thus prevent the extinction of their properties resulting from the agglomeration, they are covered with a neutral material, thus obtaining core‐shell nanostructures that can be further modified and functionalized depending on the subsequent application. In this review, we focus on discussing the properties and applications of Ag NPs and Au NPs in the medical field such as the treatment of various diseases, drug carriers, diagnostics, and many others. In addition, the following review also discusses the use and potential applications of Ag@SiO2 and Au@SiO2 core‐shell nanostructures, which can be used in cancer therapy and diagnosis, treatment of infections, or tissue engineering.

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Section: Application In Therapy and Diagnosis Of Cancermentioning

confidence: 99%

Section: Medical Application Of Ag/au@silica Core‐shell Nanostructuresmentioning

confidence: 99%

Medical Applications of Silver and Gold Nanoparticles and Core‐Shell Nanostructures Based on Silver or Gold Core: Recent Progress and Innovations

Kowalska,

Adamska,

Grobelna

2024

ChemMedChem

View full text Add to dashboard Cite

show abstract

“…LODs of 6 pg/m for SCCA and 5 pg/mL for survivin were achieved with a linear dynamic range for both analytes from 10 pg/mL to 10 μg/mL. Finally, the simultaneous determination of SCCA and CEA, also targeting cervical cancer, was performed in a microfluidic chip consisting of six functional units with a pump-free design that enabled parallel detection of multiple samples on an array of SiO 2 particles decorated with Au nanoparticles and modified with the respective antibodies in combination with Ag nanocubes labeled with Raman tags and modified with analyte-specific antibodies [ 146 ]. The LODs of SCCA and CEA achieved were 0.45 pg/mL and 0.36 pg/mL, respectively, with a dynamic range from 1 pg/mL to 1 μg/mL.…”

Section: Cancer Biomarkers Immunochemical Detection Via Sersmentioning

confidence: 99%

SERS Immunosensors for Cancer Markers Detection

et al. 2023

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Early diagnosis and monitoring are essential for the effective treatment and survival of patients with different types of malignancy. To this end, the accurate and sensitive determination of substances in human biological fluids related to cancer diagnosis and/or prognosis, i.e., cancer biomarkers, is of ultimate importance. Advancements in the field of immunodetection and nanomaterials have enabled the application of new transduction approaches for the sensitive detection of single or multiple cancer biomarkers in biological fluids. Immunosensors based on surface-enhanced Raman spectroscopy (SERS) are examples where the special properties of nanostructured materials and immunoreagents are combined to develop analytical tools that hold promise for point-of-care applications. In this frame, the subject of this review article is to present the advancements made so far regarding the immunochemical determination of cancer biomarkers by SERS. Thus, after a short introduction about the principles of both immunoassays and SERS, an extended presentation of up-to-date works regarding both single and multi-analyte determination of cancer biomarkers is presented. Finally, future perspectives on the field of SERS immunosensors for cancer markers detection are briefly discussed.

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“…The amalgamation of microfluidics with nanomaterials has yielded innovative approaches to detecting cancer-related biomarkers [ 289 ]. Gu et al [ 290 ] have fabricated a microfluidic detection platform based on an Au@SiO 2 array with a highly surface-enhanced Raman scattering (SERS) active substrate that permits the simultaneous detection of squamous cell carcinoma antigen and carcinoembryonic antigen in clinical serum samples, underscoring the potential of microfluidic chips for clinical cervical cancer diagnosis. Drug intervention, such as tannin from Spatholobi Caulis (TTS), has also emerged as a significant treatment modality for cervical cancer.…”

Section: Microfluidic Chips For Gynecological Diseasesmentioning

confidence: 99%

Revolutionizing the female reproductive system research using microfluidic chip platform

Yan,

Wu,

Zhang

et al. 2023

J Nanobiotechnol

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Comprehensively understanding the female reproductive system is crucial for safeguarding fertility and preventing diseases concerning women's health. With the capacity to simulate the intricate physio- and patho-conditions, and provide diagnostic platforms, microfluidic chips have fundamentally transformed the knowledge and management of female reproductive health, which will ultimately promote the development of more effective assisted reproductive technologies, treatments, and drug screening approaches. This review elucidates diverse microfluidic systems in mimicking the ovary, fallopian tube, uterus, placenta and cervix, and we delve into the culture of follicles and oocytes, gametes’ manipulation, cryopreservation, and permeability especially. We investigate the role of microfluidics in endometriosis and hysteromyoma, and explore their applications in ovarian cancer, endometrial cancer and cervical cancer. At last, the current status of assisted reproductive technology and integrated microfluidic devices are introduced briefly. Through delineating the multifarious advantages and challenges of the microfluidic technology, we chart a definitive course for future research in the woman health field. As the microfluidic technology continues to evolve and advance, it holds great promise for revolutionizing the diagnosis and treatment of female reproductive health issues, thus propelling us into a future where we can ultimately optimize the overall wellbeing and health of women everywhere. Graphical Abstract

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A microfluidic chip using Au@SiO2 array–based highly SERS-active substrates for ultrasensitive detection of dual cervical cancer–related biomarkers

Cited by 11 publications

References 39 publications

Medical Applications of Silver and Gold Nanoparticles and Core‐Shell Nanostructures Based on Silver or Gold Core: Recent Progress and Innovations

Medical Applications of Silver and Gold Nanoparticles and Core‐Shell Nanostructures Based on Silver or Gold Core: Recent Progress and Innovations

SERS Immunosensors for Cancer Markers Detection

Revolutionizing the female reproductive system research using microfluidic chip platform

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